Integrating a 1.5 T MRI scanner with a 6 MV accelerator: proof of concept

B.W. Raaymakers; J.J.W. Lagendijk; J.A. Overweg; J G M Kok; A.J.E. Raaijmakers; E.M. Kerkhof; R.W. van der Put; I. Meijsing; S.P.M. Crijns; F. Benedosso; M. van Vulpen; C.H.W. de Graaff; J.J.B. Allen; K.J. Brown

doi:10.1088/0031-9155/54/12/N01

Integrating a 1.5 T MRI scanner with a 6 MV accelerator: proof of concept

B.W. Raaymakers, J.J.W. Lagendijk, J.A. Overweg, J G M Kok, A.J.E. Raaijmakers, E.M. Kerkhof, R.W. van der Put, I. Meijsing, S.P.M. Crijns, F. Benedosso, M. van Vulpen, C.H.W. de Graaff, J.J.B. Allen, K.J. Brown

Research output: Contribution to journal › Article › Academic › peer-review

426 Citations (Scopus)

Abstract

At the UMC Utrecht, The Netherlands, we have constructed a prototype MRI accelerator. The prototype is a modified 6 MV Elekta (Crawley, UK) accelerator next to a modified 1.5 T Philips Achieva (Best, The Netherlands) MRI system. From the initial design onwards, modifications to both systems were aimed to yield simultaneous and unhampered operation of the MRI and the accelerator. Indeed, the simultaneous operation is shown by performing diagnostic quality 1.5 T MRI with the radiation beam on. No degradation of the performance of either system was found. The integrated 1.5 T MRI system and radiotherapy accelerator allow simultaneous irradiation and MR imaging. The full diagnostic imaging capacities of the MRI can be used; dedicated sequences for MRI-guided radiotherapy treatments will be developed. This proof of concept opens the door towards a clinical prototype to start testing MRI-guided radiation therapy (MRIgRT) in the clinic.

Original language	English
Pages (from-to)	N229-N237
Journal	Physics in Medicine and Biology
Volume	54
Issue number	12
DOIs	https://doi.org/10.1088/0031-9155/54/12/N01
Publication status	Published - 21 Jun 2009
Externally published	Yes

Keywords

Equipment Design
Equipment Failure Analysis
Magnetic Resonance Imaging
Particle Accelerators
Pilot Projects
Radiotherapy, Computer-Assisted
Systems Integration
Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't

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10.1088/0031-9155/54/12/N01

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Raaymakers, B. W., Lagendijk, J. J. W., Overweg, J. A., Kok, J. G. M., Raaijmakers, A. J. E., Kerkhof, E. M., van der Put, R. W., Meijsing, I., Crijns, S. P. M., Benedosso, F., van Vulpen, M., de Graaff, C. H. W., Allen, J. J. B., & Brown, K. J. (2009). Integrating a 1.5 T MRI scanner with a 6 MV accelerator: proof of concept. Physics in Medicine and Biology, 54(12), N229-N237. https://doi.org/10.1088/0031-9155/54/12/N01

Raaymakers, B.W. ; Lagendijk, J.J.W. ; Overweg, J.A. ; Kok, J G M ; Raaijmakers, A.J.E. ; Kerkhof, E.M. ; van der Put, R.W. ; Meijsing, I. ; Crijns, S.P.M. ; Benedosso, F. ; van Vulpen, M. ; de Graaff, C.H.W. ; Allen, J.J.B. ; Brown, K.J. / Integrating a 1.5 T MRI scanner with a 6 MV accelerator : proof of concept. In: Physics in Medicine and Biology. 2009 ; Vol. 54, No. 12. pp. N229-N237.

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title = "Integrating a 1.5 T MRI scanner with a 6 MV accelerator: proof of concept",

abstract = "At the UMC Utrecht, The Netherlands, we have constructed a prototype MRI accelerator. The prototype is a modified 6 MV Elekta (Crawley, UK) accelerator next to a modified 1.5 T Philips Achieva (Best, The Netherlands) MRI system. From the initial design onwards, modifications to both systems were aimed to yield simultaneous and unhampered operation of the MRI and the accelerator. Indeed, the simultaneous operation is shown by performing diagnostic quality 1.5 T MRI with the radiation beam on. No degradation of the performance of either system was found. The integrated 1.5 T MRI system and radiotherapy accelerator allow simultaneous irradiation and MR imaging. The full diagnostic imaging capacities of the MRI can be used; dedicated sequences for MRI-guided radiotherapy treatments will be developed. This proof of concept opens the door towards a clinical prototype to start testing MRI-guided radiation therapy (MRIgRT) in the clinic.",

keywords = "Equipment Design, Equipment Failure Analysis, Magnetic Resonance Imaging, Particle Accelerators, Pilot Projects, Radiotherapy, Computer-Assisted, Systems Integration, Evaluation Studies, Journal Article, Research Support, Non-U.S. Gov't",

author = "B.W. Raaymakers and J.J.W. Lagendijk and J.A. Overweg and Kok, {J G M} and A.J.E. Raaijmakers and E.M. Kerkhof and {van der Put}, R.W. and I. Meijsing and S.P.M. Crijns and F. Benedosso and {van Vulpen}, M. and {de Graaff}, C.H.W. and J.J.B. Allen and K.J. Brown",

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doi = "10.1088/0031-9155/54/12/N01",

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Raaymakers, BW, Lagendijk, JJW, Overweg, JA, Kok, JGM, Raaijmakers, AJE, Kerkhof, EM, van der Put, RW, Meijsing, I, Crijns, SPM, Benedosso, F, van Vulpen, M, de Graaff, CHW, Allen, JJB & Brown, KJ 2009, 'Integrating a 1.5 T MRI scanner with a 6 MV accelerator: proof of concept', Physics in Medicine and Biology, vol. 54, no. 12, pp. N229-N237. https://doi.org/10.1088/0031-9155/54/12/N01

Integrating a 1.5 T MRI scanner with a 6 MV accelerator : proof of concept. / Raaymakers, B.W.; Lagendijk, J.J.W.; Overweg, J.A.; Kok, J G M; Raaijmakers, A.J.E.; Kerkhof, E.M.; van der Put, R.W.; Meijsing, I.; Crijns, S.P.M.; Benedosso, F.; van Vulpen, M.; de Graaff, C.H.W.; Allen, J.J.B.; Brown, K.J.

In: Physics in Medicine and Biology, Vol. 54, No. 12, 21.06.2009, p. N229-N237.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Integrating a 1.5 T MRI scanner with a 6 MV accelerator

T2 - proof of concept

AU - Raaymakers, B.W.

AU - Lagendijk, J.J.W.

AU - Overweg, J.A.

AU - Kok, J G M

AU - Raaijmakers, A.J.E.

AU - Kerkhof, E.M.

AU - van der Put, R.W.

AU - Meijsing, I.

AU - Crijns, S.P.M.

AU - Benedosso, F.

AU - van Vulpen, M.

AU - de Graaff, C.H.W.

AU - Allen, J.J.B.

AU - Brown, K.J.

PY - 2009/6/21

Y1 - 2009/6/21

N2 - At the UMC Utrecht, The Netherlands, we have constructed a prototype MRI accelerator. The prototype is a modified 6 MV Elekta (Crawley, UK) accelerator next to a modified 1.5 T Philips Achieva (Best, The Netherlands) MRI system. From the initial design onwards, modifications to both systems were aimed to yield simultaneous and unhampered operation of the MRI and the accelerator. Indeed, the simultaneous operation is shown by performing diagnostic quality 1.5 T MRI with the radiation beam on. No degradation of the performance of either system was found. The integrated 1.5 T MRI system and radiotherapy accelerator allow simultaneous irradiation and MR imaging. The full diagnostic imaging capacities of the MRI can be used; dedicated sequences for MRI-guided radiotherapy treatments will be developed. This proof of concept opens the door towards a clinical prototype to start testing MRI-guided radiation therapy (MRIgRT) in the clinic.

AB - At the UMC Utrecht, The Netherlands, we have constructed a prototype MRI accelerator. The prototype is a modified 6 MV Elekta (Crawley, UK) accelerator next to a modified 1.5 T Philips Achieva (Best, The Netherlands) MRI system. From the initial design onwards, modifications to both systems were aimed to yield simultaneous and unhampered operation of the MRI and the accelerator. Indeed, the simultaneous operation is shown by performing diagnostic quality 1.5 T MRI with the radiation beam on. No degradation of the performance of either system was found. The integrated 1.5 T MRI system and radiotherapy accelerator allow simultaneous irradiation and MR imaging. The full diagnostic imaging capacities of the MRI can be used; dedicated sequences for MRI-guided radiotherapy treatments will be developed. This proof of concept opens the door towards a clinical prototype to start testing MRI-guided radiation therapy (MRIgRT) in the clinic.

KW - Equipment Design

KW - Equipment Failure Analysis

KW - Magnetic Resonance Imaging

KW - Particle Accelerators

KW - Pilot Projects

KW - Radiotherapy, Computer-Assisted

KW - Systems Integration

KW - Evaluation Studies

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1088/0031-9155/54/12/N01

DO - 10.1088/0031-9155/54/12/N01

M3 - Article

C2 - 19451689

VL - 54

SP - N229-N237

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 12

ER -

Integrating a 1.5 T MRI scanner with a 6 MV accelerator: proof of concept

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Keywords

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