Influence of process parameters on extraction equilibria for the chiral separation of amines and amino-alcohols with a chiral crown ether

M. Steensma, N.J.M. Kuipers, A.B. Haan, de, G. Kwant

    Research output: Contribution to journalArticleAcademicpeer-review

    48 Citations (Scopus)
    1 Downloads (Pure)

    Abstract

    Reactive extraction is studied as a promising chiral separation technique for commercial production scale. For chiral separation of amines and amino alcohols, a chiral crown ether was identified as a versatile enantioselective extractant. In this paper, the influence of various process conditions on the extraction performance is studied experimentally, and a predictive model is constructed based on the chemical and physical equilibria. It was found that the operational selectivity in one extraction step is mainly determined by the complexation constants between crown ether and enantiomers (which are dependent on solvent and temperature) and by the extractant concentration, whereas the distribution ratio is also strongly influenced by the pH. The model gives an excellent prediction of the operational selectivity and a good explanation for the system's responses to changes in process conditions. The model can be used as a basis for a multistage equilibrium extractor model and for conceptual process design. Under optimal process conditions, an operational selectivity >1.5 was obtained for five out of seven model compounds, with satisfying distribution ratios (D 1-10).
    Original languageEnglish
    Pages (from-to)588-597
    JournalJournal of Chemical Technology and Biotechnology
    Volume81
    Issue number4
    DOIs
    Publication statusPublished - 2006

    Fingerprint

    Dive into the research topics of 'Influence of process parameters on extraction equilibria for the chiral separation of amines and amino-alcohols with a chiral crown ether'. Together they form a unique fingerprint.

    Cite this