Influence of local auto-regulation mechanisms on flow during the muscle pump effect: a modeling approach

Joke Keijsers, Carole Leguy, Wouter Huberts, A.J. Narracott, J. Rittweger, Frans van de Vosse

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Abstract

The muscle pump effect increases venous return during muscle contraction and perfusion during muscle relaxation. To investigate the additional contribution of different local auto-regulation mechanisms, a 1D pulse wave propagation model representing the calf vasculature is combined with a local auto-regulation model, which accounts for the metabolic, myogenic and endothelial regulation mechanisms. A simulated muscle contraction results in an increased arterial flow, as observed in literature. However, the expected decrease in baseline flow in the upright position is smaller than observed in vivo. In future research, other physiological mechanisms, such as the baroreflex, will be included.
Original languageEnglish
Title of host publication4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15)
EditorsP. Nithiarasu, E. Budyn
PublisherCMBE
Pages725-728
Number of pages4
ISBN (Electronic)978-0-9562914-3-1
Publication statusPublished - 2015
Event4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15), June 29-July 1, 2015, Cachan, France - Ecole Normale Superieure de Cachan, Cachan, France
Duration: 29 Jun 20151 Jul 2015
http://www.compbiomed.net/2015/

Publication series

NameCMBE online proceedings series
Volume2015
ISSN (Print)2227-3085
ISSN (Electronic)2227-9385

Conference

Conference4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15), June 29-July 1, 2015, Cachan, France
Abbreviated titleCMBE 15
Country/TerritoryFrance
CityCachan
Period29/06/151/07/15
Internet address

Keywords

  • muscle pump effect
  • arterial and venous 1D pulse wave propagation
  • local auto-regulation

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