Abstract
The muscle pump effect increases venous return during muscle contraction and perfusion during muscle relaxation. To investigate the additional contribution of different local auto-regulation mechanisms, a 1D pulse wave propagation model representing the calf vasculature is combined with a local auto-regulation model, which accounts for the metabolic, myogenic and endothelial regulation mechanisms. A simulated muscle contraction results in an increased arterial flow, as observed in literature. However, the expected decrease in baseline flow in the upright position is smaller than observed in vivo. In future research, other physiological mechanisms, such as the baroreflex, will be included.
| Original language | English |
|---|---|
| Title of host publication | 4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15) |
| Editors | P. Nithiarasu, E. Budyn |
| Publisher | CMBE |
| Pages | 725-728 |
| Number of pages | 4 |
| ISBN (Electronic) | 978-0-9562914-3-1 |
| Publication status | Published - 2015 |
| Event | 4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15), June 29-July 1, 2015, Cachan, France - Ecole Normale Superieure de Cachan, Cachan, France Duration: 29 Jun 2015 → 1 Jul 2015 http://www.compbiomed.net/2015/ |
Publication series
| Name | CMBE online proceedings series |
|---|---|
| Volume | 2015 |
| ISSN (Print) | 2227-3085 |
| ISSN (Electronic) | 2227-9385 |
Conference
| Conference | 4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15), June 29-July 1, 2015, Cachan, France |
|---|---|
| Abbreviated title | CMBE 15 |
| Country/Territory | France |
| City | Cachan |
| Period | 29/06/15 → 1/07/15 |
| Internet address |
Keywords
- muscle pump effect
- arterial and venous 1D pulse wave propagation
- local auto-regulation