Voriconazole pharmacokinetics shows a large inter- and intrapatient variability. Inflammation is associated with changes in the expression of CYP isoenzymes. Here, we evaluated the influence of inflammation, marked by C-reactive protein (CRP) levels in blood, on the metabolism of voriconazole. Observational data showed an association between CRP level and the ratio of voriconazole N-oxide to voriconazole.
Encalada Ventura, M. A., Span, L. F. R., van den Heuvel, E. R., Groothuis, G. M. M., & Alffenaar, J. W. C. (2015). Influence of inflammation on voriconazole metabolism. Antimicrobial Agents and Chemotherapy, 59(5), 2942-2943. https://doi.org/10.1128/AAC.04789-14