Influence of inflammation on voriconazole metabolism

M.A. Encalada Ventura, L.F.R. Span, E.R. van den Heuvel, G.M.M. Groothuis, J.W.C. Alffenaar

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)
82 Downloads (Pure)


Voriconazole pharmacokinetics shows a large inter- and intrapatient variability. Inflammation is associated with changes in the expression of CYP isoenzymes. Here, we evaluated the influence of inflammation, marked by C-reactive protein (CRP) levels in blood, on the metabolism of voriconazole. Observational data showed an association between CRP level and the ratio of voriconazole N-oxide to voriconazole.
Original languageEnglish
Pages (from-to)2942-2943
JournalAntimicrobial Agents and Chemotherapy
Issue number5
Publication statusPublished - 2015


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