Invloed van groeisnelheid op de effectiviteit van Gamma Knife-behandeling van vestibulair schwannomen

Translated title of the contribution: Influence of growth rate on effectiveness of Gamma Knife treatment on vestibular schwannoma

Patrick Langenhuizen, H.B. Verheul

Research output: Contribution to journalMeeting AbstractAcademic

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Abstract

Goal: This study focused on determining the influence of the growth rate of vestibular schwannoma (VS) on the effectiveness of a Gamma Knife (GK) treatment.
Methods: All patients treated with GK after a wait-and-scan policy were included. MRI scans before and after treatment were volumetrically assessed and the pre-treatment volume doubling time (VDT) was calculated. Statistical analyses were applied to analyse the influence.
Results: The resulting patient cohort contained 311 patients with a median follow-up of 60 months, including 35 patients for which the treatment was not effective. Kaplan-Meier analyses resulted in significant differences between slow- and fast-growing VS in the 5- and 10-year success percentages (log-rank, p=0.001): 97.3% and 86.0% for the slow-growing tumors and 85.5% and 67.6% for the fast-growing tumors, respectively. Influence of the VDT on the treatment result was also determined in a Cox regression. The resulting model showed a significant (p=0.045), but small effect of the VDT on the hazard ratios.
Conclusions: By employing our unique, large database with long follow-up times, we were able to show the influence of the growth rate of VS on the GK treatment results.
Translated title of the contributionInfluence of growth rate on effectiveness of Gamma Knife treatment on vestibular schwannoma
Original languageDutch
Pages (from-to)67
Number of pages1
JournalTijdschift voor Neurologie en Neurochirurgie
Volume119
Issue number2
Publication statusPublished - 2018
EventWintermeeting NVvN - Utrecht, Netherlands
Duration: 26 Jan 201826 Jan 2018

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