Invloed van groeisnelheid op de effectiviteit van Gamma Knife-behandeling van vestibulair schwannomen

Translated title of the contribution: Influence of growth rate on effectiveness of Gamma Knife treatment on vestibular schwannoma

Patrick Langenhuizen, H.B. Verheul

Research output: Contribution to journalMeeting AbstractAcademic

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Goal: This study focused on determining the influence of the growth rate of vestibular schwannoma (VS) on the effectiveness of a Gamma Knife (GK) treatment.
Methods: All patients treated with GK after a wait-and-scan policy were included. MRI scans before and after treatment were volumetrically assessed and the pre-treatment volume doubling time (VDT) was calculated. Statistical analyses were applied to analyse the influence.
Results: The resulting patient cohort contained 311 patients with a median follow-up of 60 months, including 35 patients for which the treatment was not effective. Kaplan-Meier analyses resulted in significant differences between slow- and fast-growing VS in the 5- and 10-year success percentages (log-rank, p=0.001): 97.3% and 86.0% for the slow-growing tumors and 85.5% and 67.6% for the fast-growing tumors, respectively. Influence of the VDT on the treatment result was also determined in a Cox regression. The resulting model showed a significant (p=0.045), but small effect of the VDT on the hazard ratios.
Conclusions: By employing our unique, large database with long follow-up times, we were able to show the influence of the growth rate of VS on the GK treatment results.
Original languageDutch
Pages (from-to)67
Number of pages1
JournalTijdschift voor Neurologie en Neurochirurgie
Issue number2
Publication statusPublished - 2018
EventWintermeeting NVvN - Utrecht, Netherlands
Duration: 26 Jan 201826 Jan 2018

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