Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)
115 Downloads (Pure)

Abstract

A photocrosslinkable protein G variant was used as an adapter protein to covalently and site-specifically conjugate an antibody and an Fc-fusion protein to an oligonucleotide. This modular approach enables straightforward decoration of DNA nanostructures with complex native proteins, allowing precise control over the nanoscale spatial organization of such proteins for in vitro and in vivo biomedical applications.
Original languageEnglish
Pages (from-to)7393-7396
Number of pages4
JournalChemical Communications
Volume53
Issue number53
DOIs
Publication statusPublished - 7 Jul 2017

Keywords

  • Antibodies, Monoclonal/chemistry
  • Biomedical Research
  • DNA/chemistry
  • Humans
  • Immunoglobulin Fc Fragments/chemistry
  • Nanostructures/chemistry

Fingerprint Dive into the research topics of 'Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy'. Together they form a unique fingerprint.

Cite this