In vivo experiments with powder charcoal haemoperfusion (filmadsorber) in a pig model of hepatic failure

G.M.W. van Berlo, G.H. Groot, de, S.W. Schalm, P.P. Jansen, E.H. Vries, de, T. Fick, C. Reuvers, A.L. Boks

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    Abstract

    The filmadsorber, an experimental haemoperfusion column containing activated powder charcoal embedded in a colloidal film, has been tested in pigs with ischaemicnecrosis of the Iiver. Haemoperfusion with aflow of 200 mI/min was perfermed for a duration of 4 to 6 hours. Bile acid clearances varied between ± 52 mi/min (1 st hour) and ± 23 mI/min (6th hour). Clearances for aromatic amine acids were initially even higher (phenylalanine 115, tyrosine 112 and methionfne 46 mI/min). No ammonia was removed. Side-effects were minimal, althoug platelets feil 24 ± 15%. We conclude that haemoperfusion with the filmadsorber is weil tolerated and associated with high clearances for bile acids and some amine acids, particularly in the first hours of treatment.
    Original languageEnglish
    Pages (from-to)335-340
    JournalInternational Journal of Artificial Organs
    Volume8
    Issue number6
    Publication statusPublished - 1985

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