In vivo chemistry for pretargeted tumor imaging in live mice

Raffaella Rossin, Pascal R. Verkerk, Sandra M. van den Bosch, Roland C.M. Vulders, Iris Verel, Johan Lub, Marc S. Robillard

Research output: Contribution to journalArticleAcademicpeer-review

327 Citations (Scopus)

Abstract

Figure Presented Mice and men: An antibody conjugate with trans-cyclooctene was administered to tumor-bearing mice, and the resulting chemically tagged tumors were subsequently treated with an 111In-labeled tetrazine probe in an inverse-electrondemand Diels-Alder reaction. The adduct was formed in a remarkable 52-57% yield in vivo and used for non-invasive pretargeted tumor imaging in mice (see pietu re).

Original languageEnglish
Pages (from-to)3375-3378
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number19
DOIs
Publication statusPublished - 26 Apr 2010
Externally publishedYes

Keywords

  • Antibodies
  • Cancer
  • Diels-alder reaction
  • Molecular imaging
  • Radiochemistry

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