Abstract
Figure Presented Mice and men: An antibody conjugate with trans-cyclooctene was administered to tumor-bearing mice, and the resulting chemically tagged tumors were subsequently treated with an 111In-labeled tetrazine probe in an inverse-electrondemand Diels-Alder reaction. The adduct was formed in a remarkable 52-57% yield in vivo and used for non-invasive pretargeted tumor imaging in mice (see pietu re).
Original language | English |
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Pages (from-to) | 3375-3378 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 49 |
Issue number | 19 |
DOIs | |
Publication status | Published - 26 Apr 2010 |
Externally published | Yes |
Keywords
- Antibodies
- Cancer
- Diels-alder reaction
- Molecular imaging
- Radiochemistry