In vivo chemistry for pretargeted tumor imaging in live mice

Raffaella Rossin; Pascal R. Verkerk; Sandra M. van den Bosch; Roland C.M. Vulders; Iris Verel; Johan Lub; Marc S. Robillard

doi:10.1002/anie.200906294

In vivo chemistry for pretargeted tumor imaging in live mice

Raffaella Rossin, Pascal R. Verkerk, Sandra M. van den Bosch, Roland C.M. Vulders, Iris Verel, Johan Lub, Marc S. Robillard

Research output: Contribution to journal › Article › Academic › peer-review

432 Citations (Scopus)

Abstract

Figure Presented Mice and men: An antibody conjugate with trans-cyclooctene was administered to tumor-bearing mice, and the resulting chemically tagged tumors were subsequently treated with an ¹¹¹In-labeled tetrazine probe in an inverse-electrondemand Diels-Alder reaction. The adduct was formed in a remarkable 52-57% yield in vivo and used for non-invasive pretargeted tumor imaging in mice (see pietu re).

Original language	English
Pages (from-to)	3375-3378
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	19
DOIs	https://doi.org/10.1002/anie.200906294
Publication status	Published - 26 Apr 2010
Externally published	Yes

Keywords

Antibodies
Cancer
Diels-alder reaction
Molecular imaging
Radiochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.200906294

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title = "In vivo chemistry for pretargeted tumor imaging in live mice",

abstract = "Figure Presented Mice and men: An antibody conjugate with trans-cyclooctene was administered to tumor-bearing mice, and the resulting chemically tagged tumors were subsequently treated with an 111In-labeled tetrazine probe in an inverse-electrondemand Diels-Alder reaction. The adduct was formed in a remarkable 52-57% yield in vivo and used for non-invasive pretargeted tumor imaging in mice (see pietu re).",

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T1 - In vivo chemistry for pretargeted tumor imaging in live mice

AU - Rossin, Raffaella

AU - Verkerk, Pascal R.

AU - van den Bosch, Sandra M.

AU - Vulders, Roland C.M.

AU - Verel, Iris

AU - Lub, Johan

AU - Robillard, Marc S.

PY - 2010/4/26

Y1 - 2010/4/26

N2 - Figure Presented Mice and men: An antibody conjugate with trans-cyclooctene was administered to tumor-bearing mice, and the resulting chemically tagged tumors were subsequently treated with an 111In-labeled tetrazine probe in an inverse-electrondemand Diels-Alder reaction. The adduct was formed in a remarkable 52-57% yield in vivo and used for non-invasive pretargeted tumor imaging in mice (see pietu re).

AB - Figure Presented Mice and men: An antibody conjugate with trans-cyclooctene was administered to tumor-bearing mice, and the resulting chemically tagged tumors were subsequently treated with an 111In-labeled tetrazine probe in an inverse-electrondemand Diels-Alder reaction. The adduct was formed in a remarkable 52-57% yield in vivo and used for non-invasive pretargeted tumor imaging in mice (see pietu re).

KW - Antibodies

KW - Cancer

KW - Diels-alder reaction

KW - Molecular imaging

KW - Radiochemistry

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U2 - 10.1002/anie.200906294

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M3 - Article

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SP - 3375

EP - 3378

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 19

ER -

In vivo chemistry for pretargeted tumor imaging in live mice

Abstract

Keywords

UN SDGs

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