In-vitro investigation of the relationship between microvascular structure and ultrasound contrast agent dynamics

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Abstract

Prostate cancer (PCa) is the second leading cause of cancer mortality in men in western countries. Tumor-driven angiogenesis is a recognized hallmark of cancer. Typical features of angiogenic vasculature include increased microvascular density (MVD), smaller vessel diameter and higher tortuosity, resulting in complex blood-flow patterns. Dynamic contrast-enhanced ultrasound (DCE-US) widely provides a noninvasive diagnostic tool for PCa detection with the passage of ultrasound contrast agents (UCAs) through the prostate. Analysis of the UCA dispersion kinetics in the tumor vasculature has shown promise for PCa diagnostics, but a clear link between the estimated kinetics parameters and the underlying microvascular structure is still lacking. In this work, modeling the prostate microvasculature as a porous medium, we developed tissue-mimicking phantoms with variable pore size, representing different MVD and vessel diameter. The UCA flow through the phantoms was recorded by DCE-US, and UCA velocity and dispersion coefficient were estimated by model-based deconvolution. In general, phantoms reproducing increased MVD and smaller vessel diameter lead to increased velocity and decreased dispersion coefficient. This is line with our in-vivo findings in PCa patients. Further validation will be performed by insilico simulation and more complex in-vitro phantoms in the future.
Original languageEnglish
Title of host publication2019 IEEE International Ultrasonics Symposium, IUS 2019
Place of PublicationPiscataway
PublisherInstitute of Electrical and Electronics Engineers
Pages403-406
Number of pages4
ISBN (Electronic)978-1-7281-4596-9
DOIs
Publication statusPublished - Oct 2019
Event2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom
Duration: 6 Oct 20199 Oct 2019

Conference

Conference2019 IEEE International Ultrasonics Symposium, IUS 2019
CountryUnited Kingdom
CityGlasgow
Period6/10/199/10/19

Keywords

  • Phantoms
  • Dispersion
  • Ultrasonic imaging
  • Cancer
  • Media
  • Tumors
  • prostate cancer
  • dynamic contrast-enhanced ultrasound
  • flow dynamics
  • tumor-driven angiogenic microvasculature
  • porous media phantoms

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