In-vitro engineered human cerebral tissues mimic pathological circuit disturbances in 3D

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Abstract

In-vitro modeling of brain network disorders such as epilepsy remains a major challenge. A critical step is to develop an experimental approach that enables recapitulation of in-vivo-like three-dimensional functional complexity while allowing local modulation of the neuronal networks. Here, by promoting matrix-supported active cell reaggregation, we engineered multiregional cerebral tissues with intact 3D neuronal networks and functional interconnectivity characteristic of brain networks. Furthermore, using a multi-chambered tissue-culture chip, we show that our separated but interconnected cerebral tissues can mimic neuropathological signatures such as the propagation of epileptiform discharges.

Original languageEnglish
Article number254
Number of pages9
JournalCommunications biology
Volume5
Issue number1
DOIs
Publication statusPublished - 23 Mar 2022

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