In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves

Marcelle Uiterwijk, Anthal I.P.M. Smits, Daphne van Geemen, Bas van Klarenbosch, Sylvia Dekker, Maarten Jan Cramer, Jan Willem van Rijswijk, E.B. Lurier, A. Di Luca, M.C.P. Brugmans, T. Mes, Anton W. Bosman, Elena Aikawa, P.F. Grundeman, Carlijn V.C. Bouten (Corresponding author), Jolanda Kluin (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an affordable and practical approach for heart valve replacement; therefore, it is attractive for clinical use. This study showed no consistent collagen organization in the predefined direction of electrospun scaffolds made from a resorbable supramolecular elastomer with random or circumferentially aligned fibers, after 12 months of implantation in sheep. These unexpected findings and the observed intervalvular variability highlight the need for a mechanistic understanding of the long-term in situ remodeling processes in large animal models to improve predictability of outcome toward robust and safe clinical application.
Original languageEnglish
Pages (from-to)1187-1206
Number of pages20
JournalJACC: Basic to Translational Science
Volume5
Issue number12
Early online dateNov 2020
DOIs
Publication statusPublished - Dec 2020

Keywords

  • cell biology/structural biology
  • valvular heart disease

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