In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves

Marcelle Uiterwijk; Anthal I.P.M. Smits; Daphne van Geemen; Bas van Klarenbosch; Sylvia Dekker; Maarten Jan Cramer; Jan Willem van Rijswijk; E.B. Lurier; A. Di Luca; M.C.P. Brugmans; T. Mes; Anton W. Bosman; Elena Aikawa; P.F. Grundeman; Carlijn V.C. Bouten; Jolanda Kluin

doi:10.1016/j.jacbts.2020.09.011

In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves

Marcelle Uiterwijk, Anthal I.P.M. Smits, Daphne van Geemen, Bas van Klarenbosch, Sylvia Dekker, Maarten Jan Cramer, Jan Willem van Rijswijk, E.B. Lurier, A. Di Luca, M.C.P. Brugmans, T. Mes, Anton W. Bosman, Elena Aikawa, P.F. Grundeman, Carlijn V.C. Bouten (Corresponding author), Jolanda Kluin (Corresponding author)

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an affordable and practical approach for heart valve replacement; therefore, it is attractive for clinical use. This study showed no consistent collagen organization in the predefined direction of electrospun scaffolds made from a resorbable supramolecular elastomer with random or circumferentially aligned fibers, after 12 months of implantation in sheep. These unexpected findings and the observed intervalvular variability highlight the need for a mechanistic understanding of the long-term in situ remodeling processes in large animal models to improve predictability of outcome toward robust and safe clinical application.

Original language	English
Pages (from-to)	1187-1206
Number of pages	20
Journal	JACC: Basic to Translational Science
Volume	5
Issue number	12
Early online date	Nov 2020
DOIs	https://doi.org/10.1016/j.jacbts.2020.09.011
Publication status	Published - Dec 2020

Keywords

cell biology/structural biology
valvular heart disease

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Uiterwijk, M., Smits, A. I. P. M., van Geemen, D., van Klarenbosch, B., Dekker, S., Cramer, M. J., van Rijswijk, J. W., Lurier, E. B., Di Luca, A., Brugmans, M. C. P., Mes, T., Bosman, A. W., Aikawa, E., Grundeman, P. F., Bouten, C. V. C., & Kluin, J. (2020). In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves. JACC: Basic to Translational Science, 5(12), 1187-1206. https://doi.org/10.1016/j.jacbts.2020.09.011

Uiterwijk, Marcelle ; Smits, Anthal I.P.M. ; van Geemen, Daphne ; van Klarenbosch, Bas ; Dekker, Sylvia ; Cramer, Maarten Jan ; van Rijswijk, Jan Willem ; Lurier, E.B. ; Di Luca, A. ; Brugmans, M.C.P. ; Mes, T. ; Bosman, Anton W. ; Aikawa, Elena ; Grundeman, P.F. ; Bouten, Carlijn V.C. ; Kluin, Jolanda. / In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves. In: JACC: Basic to Translational Science. 2020 ; Vol. 5, No. 12. pp. 1187-1206.

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title = "In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves",

abstract = "In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an affordable and practical approach for heart valve replacement; therefore, it is attractive for clinical use. This study showed no consistent collagen organization in the predefined direction of electrospun scaffolds made from a resorbable supramolecular elastomer with random or circumferentially aligned fibers, after 12 months of implantation in sheep. These unexpected findings and the observed intervalvular variability highlight the need for a mechanistic understanding of the long-term in situ remodeling processes in large animal models to improve predictability of outcome toward robust and safe clinical application.",

keywords = "cell biology/structural biology, valvular heart disease",

author = "Marcelle Uiterwijk and Smits, {Anthal I.P.M.} and {van Geemen}, Daphne and {van Klarenbosch}, Bas and Sylvia Dekker and Cramer, {Maarten Jan} and {van Rijswijk}, {Jan Willem} and E.B. Lurier and {Di Luca}, A. and M.C.P. Brugmans and T. Mes and Bosman, {Anton W.} and Elena Aikawa and P.F. Grundeman and Bouten, {Carlijn V.C.} and Jolanda Kluin",

year = "2020",

month = dec,

doi = "10.1016/j.jacbts.2020.09.011",

language = "English",

volume = "5",

pages = "1187--1206",

journal = "JACC: Basic to Translational Science",

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Uiterwijk, M, Smits, AIPM , van Geemen, D, van Klarenbosch, B, Dekker, S, Cramer, MJ, van Rijswijk, JW, Lurier, EB, Di Luca, A, Brugmans, MCP, Mes, T, Bosman, AW, Aikawa, E, Grundeman, PF, Bouten, CVC & Kluin, J 2020, 'In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves', JACC: Basic to Translational Science, vol. 5, no. 12, pp. 1187-1206. https://doi.org/10.1016/j.jacbts.2020.09.011

In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves. / Uiterwijk, Marcelle; Smits, Anthal I.P.M.; van Geemen, Daphne; van Klarenbosch, Bas; Dekker, Sylvia; Cramer, Maarten Jan; van Rijswijk, Jan Willem; Lurier, E.B.; Di Luca, A.; Brugmans, M.C.P.; Mes, T.; Bosman, Anton W.; Aikawa, Elena; Grundeman, P.F.; Bouten, Carlijn V.C. (Corresponding author); Kluin, Jolanda (Corresponding author).

In: JACC: Basic to Translational Science, Vol. 5, No. 12, 12.2020, p. 1187-1206.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves

AU - Uiterwijk, Marcelle

AU - Smits, Anthal I.P.M.

AU - van Geemen, Daphne

AU - van Klarenbosch, Bas

AU - Dekker, Sylvia

AU - Cramer, Maarten Jan

AU - van Rijswijk, Jan Willem

AU - Lurier, E.B.

AU - Di Luca, A.

AU - Brugmans, M.C.P.

AU - Mes, T.

AU - Bosman, Anton W.

AU - Aikawa, Elena

AU - Grundeman, P.F.

AU - Bouten, Carlijn V.C.

AU - Kluin, Jolanda

PY - 2020/12

Y1 - 2020/12

N2 - In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an affordable and practical approach for heart valve replacement; therefore, it is attractive for clinical use. This study showed no consistent collagen organization in the predefined direction of electrospun scaffolds made from a resorbable supramolecular elastomer with random or circumferentially aligned fibers, after 12 months of implantation in sheep. These unexpected findings and the observed intervalvular variability highlight the need for a mechanistic understanding of the long-term in situ remodeling processes in large animal models to improve predictability of outcome toward robust and safe clinical application.

AB - In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an affordable and practical approach for heart valve replacement; therefore, it is attractive for clinical use. This study showed no consistent collagen organization in the predefined direction of electrospun scaffolds made from a resorbable supramolecular elastomer with random or circumferentially aligned fibers, after 12 months of implantation in sheep. These unexpected findings and the observed intervalvular variability highlight the need for a mechanistic understanding of the long-term in situ remodeling processes in large animal models to improve predictability of outcome toward robust and safe clinical application.

KW - cell biology/structural biology

KW - valvular heart disease

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U2 - 10.1016/j.jacbts.2020.09.011

DO - 10.1016/j.jacbts.2020.09.011

M3 - Article

C2 - 33426376

VL - 5

SP - 1187

EP - 1206

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

SN - 2452-302X

IS - 12

ER -

In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves

Abstract

Keywords

Access to Document

One step closer to regenerative heart valves and stents

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