Abstract
In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an affordable and practical approach for heart valve replacement; therefore, it is attractive for clinical use. This study showed no consistent collagen organization in the predefined direction of electrospun scaffolds made from a resorbable supramolecular elastomer with random or circumferentially aligned fibers, after 12 months of implantation in sheep. These unexpected findings and the observed intervalvular variability highlight the need for a mechanistic understanding of the long-term in situ remodeling processes in large animal models to improve predictability of outcome toward robust and safe clinical application.
Original language | English |
---|---|
Pages (from-to) | 1187-1206 |
Number of pages | 20 |
Journal | JACC: Basic to Translational Science |
Volume | 5 |
Issue number | 12 |
Early online date | Nov 2020 |
DOIs | |
Publication status | Published - Dec 2020 |
Keywords
- cell biology/structural biology
- valvular heart disease
Fingerprint
Dive into the research topics of 'In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves'. Together they form a unique fingerprint.Press / Media
-
One step closer to regenerative heart valves and stents
Carlijn V.C. Bouten & Anthal I.P.M. Smits
7/01/21 → 8/01/21
3 items of Media coverage
Press/Media: Expert Comment