We present a formal analysis of ribosome kinetics using probabilistic model checking and the tool Prism. We compute different parameters of the model, like probabilities of translation errors and average insertion times per codon. The model predicts strong correlation to the quotient of the concentrations of the socalled cognate and near-cognate tRNAs, in accord with experimental findings and other studies. Using piecewise analysis of the model, we are able to give an analytical
explanation of this observation.
|Title of host publication||Proceedings of COMPMOD 2008 ( Workshop on Computational Models for Cell Processes, Turku, Finland, May 27, 2008)|
|Editors||R.J. Back, I. Petre|
|Place of Publication||Turku, Finland|
|Publisher||Turku Centre for Computer Science|
|Publication status||Published - 2008|
|Name||TUCS General Publications|