Improving peri-prosthetic bone adaptation around cementless hip stems: a clinical and finite element study

René H.M. ten Broeke, Maria Tarala, Jacobus J.C. Arts, Dennis W. Janssen, Nico Verdonschot, Rudolph G.T. Geesink

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)


This study assessed whether the Symax™ implant, a modification of the Omnifit® stem (in terms of shape, proximal coating and distal surface treatment), would yield improved bone remodelling in a clinical DEXA study, and if these results could be predicted in a finite element (FE) simulation study.In a randomized clinical trial, 2 year DEXA measurements between the uncemented Symax™ and Omnifit® stem (both n=25) showed bone mineral density (BMD) loss in Gruen zone 7 of 14% and 20%, respectively (p<0.05). In contrast, the FE models predicted a 28% (Symax™) and 26% (Omnifit®) bone loss. When the distal treatment to the Symax™ was not modelled in the simulation, bone loss of 35% was predicted, suggesting the benefit of this surface treatment for proximal bone maintenance.The theoretical concept for enhanced proximal bone loading by the Symax™, and the predicted remodelling pattern were confirmed by DEXA-results, but there was no quantitative match between clinical and FE findings. This was due to a simulation based on incomplete assumptions concerning the yet unknown biological and mechanical effects of the new coating and surface treatment.

Original languageEnglish
Pages (from-to)345-353
Number of pages9
JournalMedical Engineering and Physics
Issue number3
Publication statusPublished - Mar 2014


  • Bone mineral density
  • Cementless hip arthroplasty
  • DEXA
  • Finite element analysis


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