Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator

Shauna D. O’Donovan (Corresponding author), Michael Lenz, Gijs H. Goossens, Carla J.H. van der Kallen, Simone J.M.P. Eussen, Coen D.A. Stehouwer, Marleen M. van Greevenbroek, Miranda T. Schram, Simone J. Sep, Ralf L.M. Peeters, Ellen E. Blaak, Natal A.W. van Riel, Theo M.C.M. de Kok, Ilja C.W. Arts

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The Muscle Insulin Sensitivity Index (MISI) has been developed to estimate muscle-specific insulin sensitivity based on oral glucose tolerance test (OGTT) data. To date, the score has been implemented with considerable variation in literature and initial positive evaluations were not reproduced in subsequent studies. In this study, we investigate the computation of MISI on oral OGTT data with differing sampling schedules and aim to standardise and improve its calculation. Seven time point OGTT data for 2631 individuals from the Maastricht Study and seven time point OGTT data combined with a hyperinsulinemic-euglycaemic clamp for 71 individuals from the PRESERVE Study were used to evaluate the performance of MISI. MISI was computed on subsets of OGTT data representing four and five time point sampling schedules to determine minimal requirements for accurate computation of the score. A modified MISI computed on cubic splines of the measured data, resulting in improved identification of glucose peak and nadir, was compared with the original method yielding an increased correlation (ρ = 0.576) with the clamp measurement of peripheral insulin sensitivity as compared to the original method (ρ = 0.513). Finally, a standalone MISI calculator was developed allowing for a standardised method of calculation using both the original and improved methods.

LanguageEnglish
Article number9388
Number of pages10
JournalScientific Reports
Volume9
Issue number1
DOIs
StatePublished - 28 Jun 2019

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Glucose Tolerance Test
Insulin Resistance
Muscles
Appointments and Schedules
Glucose Clamp Technique
Glucose

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O’Donovan, S. D., Lenz, M., Goossens, G. H., van der Kallen, C. J. H., Eussen, S. J. M. P., Stehouwer, C. D. A., ... Arts, I. C. W. (2019). Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator. Scientific Reports, 9(1), [9388]. DOI: 10.1038/s41598-019-45858-w
O’Donovan, Shauna D. ; Lenz, Michael ; Goossens, Gijs H. ; van der Kallen, Carla J.H. ; Eussen, Simone J.M.P. ; Stehouwer, Coen D.A. ; van Greevenbroek, Marleen M. ; Schram, Miranda T. ; Sep, Simone J. ; Peeters, Ralf L.M. ; Blaak, Ellen E. ; van Riel, Natal A.W. ; de Kok, Theo M.C.M. ; Arts, Ilja C.W./ Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data : the MISI Calculator. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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title = "Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator",
abstract = "The Muscle Insulin Sensitivity Index (MISI) has been developed to estimate muscle-specific insulin sensitivity based on oral glucose tolerance test (OGTT) data. To date, the score has been implemented with considerable variation in literature and initial positive evaluations were not reproduced in subsequent studies. In this study, we investigate the computation of MISI on oral OGTT data with differing sampling schedules and aim to standardise and improve its calculation. Seven time point OGTT data for 2631 individuals from the Maastricht Study and seven time point OGTT data combined with a hyperinsulinemic-euglycaemic clamp for 71 individuals from the PRESERVE Study were used to evaluate the performance of MISI. MISI was computed on subsets of OGTT data representing four and five time point sampling schedules to determine minimal requirements for accurate computation of the score. A modified MISI computed on cubic splines of the measured data, resulting in improved identification of glucose peak and nadir, was compared with the original method yielding an increased correlation (ρ = 0.576) with the clamp measurement of peripheral insulin sensitivity as compared to the original method (ρ = 0.513). Finally, a standalone MISI calculator was developed allowing for a standardised method of calculation using both the original and improved methods.",
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O’Donovan, SD, Lenz, M, Goossens, GH, van der Kallen, CJH, Eussen, SJMP, Stehouwer, CDA, van Greevenbroek, MM, Schram, MT, Sep, SJ, Peeters, RLM, Blaak, EE, van Riel, NAW, de Kok, TMCM & Arts, ICW 2019, 'Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator' Scientific Reports, vol. 9, no. 1, 9388. DOI: 10.1038/s41598-019-45858-w

Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data : the MISI Calculator. / O’Donovan, Shauna D. (Corresponding author); Lenz, Michael; Goossens, Gijs H.; van der Kallen, Carla J.H.; Eussen, Simone J.M.P.; Stehouwer, Coen D.A.; van Greevenbroek, Marleen M.; Schram, Miranda T.; Sep, Simone J.; Peeters, Ralf L.M.; Blaak, Ellen E.; van Riel, Natal A.W.; de Kok, Theo M.C.M.; Arts, Ilja C.W.

In: Scientific Reports, Vol. 9, No. 1, 9388, 28.06.2019.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Lenz,Michael

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AU - van der Kallen,Carla J.H.

AU - Eussen,Simone J.M.P.

AU - Stehouwer,Coen D.A.

AU - van Greevenbroek,Marleen M.

AU - Schram,Miranda T.

AU - Sep,Simone J.

AU - Peeters,Ralf L.M.

AU - Blaak,Ellen E.

AU - van Riel,Natal A.W.

AU - de Kok,Theo M.C.M.

AU - Arts,Ilja C.W.

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N2 - The Muscle Insulin Sensitivity Index (MISI) has been developed to estimate muscle-specific insulin sensitivity based on oral glucose tolerance test (OGTT) data. To date, the score has been implemented with considerable variation in literature and initial positive evaluations were not reproduced in subsequent studies. In this study, we investigate the computation of MISI on oral OGTT data with differing sampling schedules and aim to standardise and improve its calculation. Seven time point OGTT data for 2631 individuals from the Maastricht Study and seven time point OGTT data combined with a hyperinsulinemic-euglycaemic clamp for 71 individuals from the PRESERVE Study were used to evaluate the performance of MISI. MISI was computed on subsets of OGTT data representing four and five time point sampling schedules to determine minimal requirements for accurate computation of the score. A modified MISI computed on cubic splines of the measured data, resulting in improved identification of glucose peak and nadir, was compared with the original method yielding an increased correlation (ρ = 0.576) with the clamp measurement of peripheral insulin sensitivity as compared to the original method (ρ = 0.513). Finally, a standalone MISI calculator was developed allowing for a standardised method of calculation using both the original and improved methods.

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O’Donovan SD, Lenz M, Goossens GH, van der Kallen CJH, Eussen SJMP, Stehouwer CDA et al. Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator. Scientific Reports. 2019 Jun 28;9(1). 9388. Available from, DOI: 10.1038/s41598-019-45858-w