Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method

F.J. Verbaan, S.M. Bal, D.J. Berg, van den, J.A. Dijksman, M. Hecke, van, H. Verpoorten, A. Berg, van den, R. Luttge, J.A. Bouwstra

Research output: Contribution to journalArticleAcademicpeer-review

131 Citations (Scopus)

Abstract

An electrical applicator was designed, which can pierce short microneedles into the skin with a predefined velocity. Three different shapes of microneedles were used, namely 300 µm assembled hollow metal microneedle arrays, 300 µm solid metal microneedle arrays and 245 µm hollow silicon microneedle arrays. The latter are available as 4 × 4, 6 × 6 and 9 × 9 arrays. When using a velocity of 1 or 3 m/s reproducible piercing of dermatomed and full thickness human skin was evident from the appearance of blue spots on the dermal side of the skin after Trypan Blue treatment and the presence of fluorescently labeled particles in dermatomed skin. Manual piercing did not result in the appearance of blue spots. Transport studies revealed that i) piercing of microneedles with a predefined velocity into human skin resulted in a drastic enhancement of the Cascade Blue (CB, Mw 538) transport, ii) A higher piercing velocity resulted in a higher CB transport rate, iii) The CB transport rate was also dependent on the shape of the microneedles and iv) no difference in transport rate was observed between 4 × 4, 6 × 6 and 9 × 9 hollow silicon microneedle arrays. © 2008 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)80-88
Number of pages9
JournalJournal of Controlled Release
Volume128
Issue number1
DOIs
Publication statusPublished - 2008

Fingerprint

Skin
Silicon
Metals
Trypan Blue

Cite this

Verbaan, F. J., Bal, S. M., Berg, van den, D. J., Dijksman, J. A., Hecke, van, M., Verpoorten, H., ... Bouwstra, J. A. (2008). Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method. Journal of Controlled Release, 128(1), 80-88. https://doi.org/10.1016/j.jconrel.2008.02.009
Verbaan, F.J. ; Bal, S.M. ; Berg, van den, D.J. ; Dijksman, J.A. ; Hecke, van, M. ; Verpoorten, H. ; Berg, van den, A. ; Luttge, R. ; Bouwstra, J.A. / Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method. In: Journal of Controlled Release. 2008 ; Vol. 128, No. 1. pp. 80-88.
@article{3ab9ef051722483f8f55f85674e615d4,
title = "Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method",
abstract = "An electrical applicator was designed, which can pierce short microneedles into the skin with a predefined velocity. Three different shapes of microneedles were used, namely 300 µm assembled hollow metal microneedle arrays, 300 µm solid metal microneedle arrays and 245 µm hollow silicon microneedle arrays. The latter are available as 4 × 4, 6 × 6 and 9 × 9 arrays. When using a velocity of 1 or 3 m/s reproducible piercing of dermatomed and full thickness human skin was evident from the appearance of blue spots on the dermal side of the skin after Trypan Blue treatment and the presence of fluorescently labeled particles in dermatomed skin. Manual piercing did not result in the appearance of blue spots. Transport studies revealed that i) piercing of microneedles with a predefined velocity into human skin resulted in a drastic enhancement of the Cascade Blue (CB, Mw 538) transport, ii) A higher piercing velocity resulted in a higher CB transport rate, iii) The CB transport rate was also dependent on the shape of the microneedles and iv) no difference in transport rate was observed between 4 × 4, 6 × 6 and 9 × 9 hollow silicon microneedle arrays. {\circledC} 2008 Elsevier B.V. All rights reserved.",
author = "F.J. Verbaan and S.M. Bal and {Berg, van den}, D.J. and J.A. Dijksman and {Hecke, van}, M. and H. Verpoorten and {Berg, van den}, A. and R. Luttge and J.A. Bouwstra",
year = "2008",
doi = "10.1016/j.jconrel.2008.02.009",
language = "English",
volume = "128",
pages = "80--88",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier",
number = "1",

}

Verbaan, FJ, Bal, SM, Berg, van den, DJ, Dijksman, JA, Hecke, van, M, Verpoorten, H, Berg, van den, A, Luttge, R & Bouwstra, JA 2008, 'Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method', Journal of Controlled Release, vol. 128, no. 1, pp. 80-88. https://doi.org/10.1016/j.jconrel.2008.02.009

Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method. / Verbaan, F.J.; Bal, S.M.; Berg, van den, D.J.; Dijksman, J.A.; Hecke, van, M.; Verpoorten, H.; Berg, van den, A.; Luttge, R.; Bouwstra, J.A.

In: Journal of Controlled Release, Vol. 128, No. 1, 2008, p. 80-88.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method

AU - Verbaan, F.J.

AU - Bal, S.M.

AU - Berg, van den, D.J.

AU - Dijksman, J.A.

AU - Hecke, van, M.

AU - Verpoorten, H.

AU - Berg, van den, A.

AU - Luttge, R.

AU - Bouwstra, J.A.

PY - 2008

Y1 - 2008

N2 - An electrical applicator was designed, which can pierce short microneedles into the skin with a predefined velocity. Three different shapes of microneedles were used, namely 300 µm assembled hollow metal microneedle arrays, 300 µm solid metal microneedle arrays and 245 µm hollow silicon microneedle arrays. The latter are available as 4 × 4, 6 × 6 and 9 × 9 arrays. When using a velocity of 1 or 3 m/s reproducible piercing of dermatomed and full thickness human skin was evident from the appearance of blue spots on the dermal side of the skin after Trypan Blue treatment and the presence of fluorescently labeled particles in dermatomed skin. Manual piercing did not result in the appearance of blue spots. Transport studies revealed that i) piercing of microneedles with a predefined velocity into human skin resulted in a drastic enhancement of the Cascade Blue (CB, Mw 538) transport, ii) A higher piercing velocity resulted in a higher CB transport rate, iii) The CB transport rate was also dependent on the shape of the microneedles and iv) no difference in transport rate was observed between 4 × 4, 6 × 6 and 9 × 9 hollow silicon microneedle arrays. © 2008 Elsevier B.V. All rights reserved.

AB - An electrical applicator was designed, which can pierce short microneedles into the skin with a predefined velocity. Three different shapes of microneedles were used, namely 300 µm assembled hollow metal microneedle arrays, 300 µm solid metal microneedle arrays and 245 µm hollow silicon microneedle arrays. The latter are available as 4 × 4, 6 × 6 and 9 × 9 arrays. When using a velocity of 1 or 3 m/s reproducible piercing of dermatomed and full thickness human skin was evident from the appearance of blue spots on the dermal side of the skin after Trypan Blue treatment and the presence of fluorescently labeled particles in dermatomed skin. Manual piercing did not result in the appearance of blue spots. Transport studies revealed that i) piercing of microneedles with a predefined velocity into human skin resulted in a drastic enhancement of the Cascade Blue (CB, Mw 538) transport, ii) A higher piercing velocity resulted in a higher CB transport rate, iii) The CB transport rate was also dependent on the shape of the microneedles and iv) no difference in transport rate was observed between 4 × 4, 6 × 6 and 9 × 9 hollow silicon microneedle arrays. © 2008 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.jconrel.2008.02.009

DO - 10.1016/j.jconrel.2008.02.009

M3 - Article

C2 - 18394741

VL - 128

SP - 80

EP - 88

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

IS - 1

ER -