Improved biocompatibility and pharmacokinetics of silica nanoparticles by means of a lipid coating: A multimodality investigation

Matti M. Van Schooneveld, Esad Vucic, Rolf Koole, Yu Zhou, Joanne Stocks, David P. Cormode, Cheuk Y. Tang, Ronald E. Gordon, Klaas Nicolay, Andries Meijerink, Zahi A. Fayad, Willem J.M. Mulder

Research output: Contribution to journalArticleAcademicpeer-review

188 Citations (Scopus)

Abstract

Silica is a promising carrier material for nanoparticle-facilitated drug delivery, gene therapy, and molecular imaging. Understanding of their pharmacokinetics is important to resolve bioapplicability issues. Here we report an extensive study on bare and lipid-coated silica nanoparticles in mice. Results obtained by use of a wide variety of techniques (fluorescence imaging, inductively coupled plasma mass spectrometry, magnetic resonance imaging, confocal laser scanning microscopy, and transmission electron microscopy) showed that the lipid coating, which enables straightforward functionalization and introduction of multiple properties, increases bioapplicability and improves pharmacokinetics.

Original languageEnglish
Pages (from-to)2517-2525
Number of pages9
JournalNano Letters
Volume8
Issue number8
DOIs
Publication statusPublished - Aug 2008

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