Impaired social functioning in children with narcolepsy

Laury Quaedackers (Corresponding author), Merel M. van Gilst, Petra van Mierlo, Gert-Jan Lammers, Karlien Dhondt, Pauline Amesz, Els Peeters, Danielle Hendriks, Nele Vandenbussche, Sigrid Pillen, Sebastiaan Overeem

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Study Objectives To explore impairments in social functioning in children with narcolepsy compared to healthy children. Methods Parents of 53 pediatric patients with narcolepsy type 1 and 64 matched healthy children completed the Social Responsiveness Scale (SRS) and the Child Behavior Checklist 6-18 (CBCL 6-18). Results Patients scored significantly higher on the total score of the SRS (median 56, interquartile range [IQR] 23.5) compared to controls (median 44.5, IQR 8.5, U = 797.0, p < 0.001). Patients also scored higher on the sum of the CBCL 6-18 subscales indicative of social functioning (Withdrawn/Depressed, Social Problems, and Thought Problems; median 183, IQR 30.5) compared to controls (median 155, IQR 13, U = 500.0, p < 0.001). A total of 24 patients (45.3%) reported at least mild-to-moderate difficulties in social functioning compared to seven controls (10.9%, χ 2 = 17.165, p < 0.001). Eleven patients (20.8%) and only one control (1.6%) had T scores above 75, which points to severely impaired social functioning (χ 2 = 11.602, p = 0.001). Within the patient group, girls reported mild-to-moderate difficulties in social functioning significantly more often compared to boys on the SRS (77.8% versus 28.6%, χ 2 = 17.560, p < 0.001). Conclusions Impaired social functioning is common in children with narcolepsy type 1, especially in girls. Questionnaires such as the SRS and the CBCL 6-18 may help in early detection of social problems in pediatric narcolepsy. Recognition of these problems could be valuable in the management of young people with narcolepsy.

LanguageEnglish
JournalSleep
Volume42
Issue number2
Early online date23 Nov 2018
DOIs
StatePublished - 1 Feb 2019

Fingerprint

Narcolepsy
Child Behavior
Checklist
Social Problems
Pediatrics
Parents

Keywords

  • behavior
  • Child Behavior Checklist
  • narcolepsy
  • NT1
  • pediatric
  • social
  • Social Responsiveness Scale

Cite this

Quaedackers, Laury ; van Gilst, Merel M. ; van Mierlo, Petra ; Lammers, Gert-Jan ; Dhondt, Karlien ; Amesz, Pauline ; Peeters, Els ; Hendriks, Danielle ; Vandenbussche, Nele ; Pillen, Sigrid ; Overeem, Sebastiaan. / Impaired social functioning in children with narcolepsy. In: Sleep. 2019 ; Vol. 42, No. 2.
@article{33d345b1b8154b7dba7f00ef1691dbdd,
title = "Impaired social functioning in children with narcolepsy",
abstract = "Study Objectives To explore impairments in social functioning in children with narcolepsy compared to healthy children. Methods Parents of 53 pediatric patients with narcolepsy type 1 and 64 matched healthy children completed the Social Responsiveness Scale (SRS) and the Child Behavior Checklist 6-18 (CBCL 6-18). Results Patients scored significantly higher on the total score of the SRS (median 56, interquartile range [IQR] 23.5) compared to controls (median 44.5, IQR 8.5, U = 797.0, p < 0.001). Patients also scored higher on the sum of the CBCL 6-18 subscales indicative of social functioning (Withdrawn/Depressed, Social Problems, and Thought Problems; median 183, IQR 30.5) compared to controls (median 155, IQR 13, U = 500.0, p < 0.001). A total of 24 patients (45.3{\%}) reported at least mild-to-moderate difficulties in social functioning compared to seven controls (10.9{\%}, χ 2 = 17.165, p < 0.001). Eleven patients (20.8{\%}) and only one control (1.6{\%}) had T scores above 75, which points to severely impaired social functioning (χ 2 = 11.602, p = 0.001). Within the patient group, girls reported mild-to-moderate difficulties in social functioning significantly more often compared to boys on the SRS (77.8{\%} versus 28.6{\%}, χ 2 = 17.560, p < 0.001). Conclusions Impaired social functioning is common in children with narcolepsy type 1, especially in girls. Questionnaires such as the SRS and the CBCL 6-18 may help in early detection of social problems in pediatric narcolepsy. Recognition of these problems could be valuable in the management of young people with narcolepsy.",
keywords = "behavior, Child Behavior Checklist, narcolepsy, NT1, pediatric, social, Social Responsiveness Scale",
author = "Laury Quaedackers and {van Gilst}, {Merel M.} and {van Mierlo}, Petra and Gert-Jan Lammers and Karlien Dhondt and Pauline Amesz and Els Peeters and Danielle Hendriks and Nele Vandenbussche and Sigrid Pillen and Sebastiaan Overeem",
year = "2019",
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Quaedackers, L, van Gilst, MM, van Mierlo, P, Lammers, G-J, Dhondt, K, Amesz, P, Peeters, E, Hendriks, D, Vandenbussche, N, Pillen, S & Overeem, S 2019, 'Impaired social functioning in children with narcolepsy' Sleep, vol. 42, no. 2. DOI: 10.1093/sleep/zsy228

Impaired social functioning in children with narcolepsy. / Quaedackers, Laury (Corresponding author); van Gilst, Merel M.; van Mierlo, Petra; Lammers, Gert-Jan; Dhondt, Karlien; Amesz, Pauline; Peeters, Els; Hendriks, Danielle; Vandenbussche, Nele; Pillen, Sigrid; Overeem, Sebastiaan.

In: Sleep, Vol. 42, No. 2, 01.02.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Impaired social functioning in children with narcolepsy

AU - Quaedackers,Laury

AU - van Gilst,Merel M.

AU - van Mierlo,Petra

AU - Lammers,Gert-Jan

AU - Dhondt,Karlien

AU - Amesz,Pauline

AU - Peeters,Els

AU - Hendriks,Danielle

AU - Vandenbussche,Nele

AU - Pillen,Sigrid

AU - Overeem,Sebastiaan

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Study Objectives To explore impairments in social functioning in children with narcolepsy compared to healthy children. Methods Parents of 53 pediatric patients with narcolepsy type 1 and 64 matched healthy children completed the Social Responsiveness Scale (SRS) and the Child Behavior Checklist 6-18 (CBCL 6-18). Results Patients scored significantly higher on the total score of the SRS (median 56, interquartile range [IQR] 23.5) compared to controls (median 44.5, IQR 8.5, U = 797.0, p < 0.001). Patients also scored higher on the sum of the CBCL 6-18 subscales indicative of social functioning (Withdrawn/Depressed, Social Problems, and Thought Problems; median 183, IQR 30.5) compared to controls (median 155, IQR 13, U = 500.0, p < 0.001). A total of 24 patients (45.3%) reported at least mild-to-moderate difficulties in social functioning compared to seven controls (10.9%, χ 2 = 17.165, p < 0.001). Eleven patients (20.8%) and only one control (1.6%) had T scores above 75, which points to severely impaired social functioning (χ 2 = 11.602, p = 0.001). Within the patient group, girls reported mild-to-moderate difficulties in social functioning significantly more often compared to boys on the SRS (77.8% versus 28.6%, χ 2 = 17.560, p < 0.001). Conclusions Impaired social functioning is common in children with narcolepsy type 1, especially in girls. Questionnaires such as the SRS and the CBCL 6-18 may help in early detection of social problems in pediatric narcolepsy. Recognition of these problems could be valuable in the management of young people with narcolepsy.

AB - Study Objectives To explore impairments in social functioning in children with narcolepsy compared to healthy children. Methods Parents of 53 pediatric patients with narcolepsy type 1 and 64 matched healthy children completed the Social Responsiveness Scale (SRS) and the Child Behavior Checklist 6-18 (CBCL 6-18). Results Patients scored significantly higher on the total score of the SRS (median 56, interquartile range [IQR] 23.5) compared to controls (median 44.5, IQR 8.5, U = 797.0, p < 0.001). Patients also scored higher on the sum of the CBCL 6-18 subscales indicative of social functioning (Withdrawn/Depressed, Social Problems, and Thought Problems; median 183, IQR 30.5) compared to controls (median 155, IQR 13, U = 500.0, p < 0.001). A total of 24 patients (45.3%) reported at least mild-to-moderate difficulties in social functioning compared to seven controls (10.9%, χ 2 = 17.165, p < 0.001). Eleven patients (20.8%) and only one control (1.6%) had T scores above 75, which points to severely impaired social functioning (χ 2 = 11.602, p = 0.001). Within the patient group, girls reported mild-to-moderate difficulties in social functioning significantly more often compared to boys on the SRS (77.8% versus 28.6%, χ 2 = 17.560, p < 0.001). Conclusions Impaired social functioning is common in children with narcolepsy type 1, especially in girls. Questionnaires such as the SRS and the CBCL 6-18 may help in early detection of social problems in pediatric narcolepsy. Recognition of these problems could be valuable in the management of young people with narcolepsy.

KW - behavior

KW - Child Behavior Checklist

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KW - NT1

KW - pediatric

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KW - Social Responsiveness Scale

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Quaedackers L, van Gilst MM, van Mierlo P, Lammers G-J, Dhondt K, Amesz P et al. Impaired social functioning in children with narcolepsy. Sleep. 2019 Feb 1;42(2). Available from, DOI: 10.1093/sleep/zsy228