Abstract
Study Objectives To explore impairments in social functioning in children with narcolepsy compared to healthy children. Methods Parents of 53 pediatric patients with narcolepsy type 1 and 64 matched healthy children completed the Social Responsiveness Scale (SRS) and the Child Behavior Checklist 6-18 (CBCL 6-18). Results Patients scored significantly higher on the total score of the SRS (median 56, interquartile range [IQR] 23.5) compared to controls (median 44.5, IQR 8.5, U = 797.0, p < 0.001). Patients also scored higher on the sum of the CBCL 6-18 subscales indicative of social functioning (Withdrawn/Depressed, Social Problems, and Thought Problems; median 183, IQR 30.5) compared to controls (median 155, IQR 13, U = 500.0, p < 0.001). A total of 24 patients (45.3%) reported at least mild-to-moderate difficulties in social functioning compared to seven controls (10.9%, χ 2 = 17.165, p < 0.001). Eleven patients (20.8%) and only one control (1.6%) had T scores above 75, which points to severely impaired social functioning (χ 2 = 11.602, p = 0.001). Within the patient group, girls reported mild-to-moderate difficulties in social functioning significantly more often compared to boys on the SRS (77.8% versus 28.6%, χ 2 = 17.560, p < 0.001). Conclusions Impaired social functioning is common in children with narcolepsy type 1, especially in girls. Questionnaires such as the SRS and the CBCL 6-18 may help in early detection of social problems in pediatric narcolepsy. Recognition of these problems could be valuable in the management of young people with narcolepsy.
| Language | English |
|---|---|
| Journal | Sleep |
| Volume | 42 |
| Issue number | 2 |
| Early online date | 23 Nov 2018 |
| DOIs | |
| State | Published - 1 Feb 2019 |
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Keywords
- behavior
- Child Behavior Checklist
- narcolepsy
- NT1
- pediatric
- social
- Social Responsiveness Scale
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Impaired social functioning in children with narcolepsy. / Quaedackers, Laury (Corresponding author); van Gilst, Merel M.; van Mierlo, Petra; Lammers, Gert-Jan; Dhondt, Karlien; Amesz, Pauline; Peeters, Els; Hendriks, Danielle; Vandenbussche, Nele; Pillen, Sigrid; Overeem, Sebastiaan.
In: Sleep, Vol. 42, No. 2, 01.02.2019.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Impaired social functioning in children with narcolepsy
AU - Quaedackers,Laury
AU - van Gilst,Merel M.
AU - van Mierlo,Petra
AU - Lammers,Gert-Jan
AU - Dhondt,Karlien
AU - Amesz,Pauline
AU - Peeters,Els
AU - Hendriks,Danielle
AU - Vandenbussche,Nele
AU - Pillen,Sigrid
AU - Overeem,Sebastiaan
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Study Objectives To explore impairments in social functioning in children with narcolepsy compared to healthy children. Methods Parents of 53 pediatric patients with narcolepsy type 1 and 64 matched healthy children completed the Social Responsiveness Scale (SRS) and the Child Behavior Checklist 6-18 (CBCL 6-18). Results Patients scored significantly higher on the total score of the SRS (median 56, interquartile range [IQR] 23.5) compared to controls (median 44.5, IQR 8.5, U = 797.0, p < 0.001). Patients also scored higher on the sum of the CBCL 6-18 subscales indicative of social functioning (Withdrawn/Depressed, Social Problems, and Thought Problems; median 183, IQR 30.5) compared to controls (median 155, IQR 13, U = 500.0, p < 0.001). A total of 24 patients (45.3%) reported at least mild-to-moderate difficulties in social functioning compared to seven controls (10.9%, χ 2 = 17.165, p < 0.001). Eleven patients (20.8%) and only one control (1.6%) had T scores above 75, which points to severely impaired social functioning (χ 2 = 11.602, p = 0.001). Within the patient group, girls reported mild-to-moderate difficulties in social functioning significantly more often compared to boys on the SRS (77.8% versus 28.6%, χ 2 = 17.560, p < 0.001). Conclusions Impaired social functioning is common in children with narcolepsy type 1, especially in girls. Questionnaires such as the SRS and the CBCL 6-18 may help in early detection of social problems in pediatric narcolepsy. Recognition of these problems could be valuable in the management of young people with narcolepsy.
AB - Study Objectives To explore impairments in social functioning in children with narcolepsy compared to healthy children. Methods Parents of 53 pediatric patients with narcolepsy type 1 and 64 matched healthy children completed the Social Responsiveness Scale (SRS) and the Child Behavior Checklist 6-18 (CBCL 6-18). Results Patients scored significantly higher on the total score of the SRS (median 56, interquartile range [IQR] 23.5) compared to controls (median 44.5, IQR 8.5, U = 797.0, p < 0.001). Patients also scored higher on the sum of the CBCL 6-18 subscales indicative of social functioning (Withdrawn/Depressed, Social Problems, and Thought Problems; median 183, IQR 30.5) compared to controls (median 155, IQR 13, U = 500.0, p < 0.001). A total of 24 patients (45.3%) reported at least mild-to-moderate difficulties in social functioning compared to seven controls (10.9%, χ 2 = 17.165, p < 0.001). Eleven patients (20.8%) and only one control (1.6%) had T scores above 75, which points to severely impaired social functioning (χ 2 = 11.602, p = 0.001). Within the patient group, girls reported mild-to-moderate difficulties in social functioning significantly more often compared to boys on the SRS (77.8% versus 28.6%, χ 2 = 17.560, p < 0.001). Conclusions Impaired social functioning is common in children with narcolepsy type 1, especially in girls. Questionnaires such as the SRS and the CBCL 6-18 may help in early detection of social problems in pediatric narcolepsy. Recognition of these problems could be valuable in the management of young people with narcolepsy.
KW - behavior
KW - Child Behavior Checklist
KW - narcolepsy
KW - NT1
KW - pediatric
KW - social
KW - Social Responsiveness Scale
UR - http://www.scopus.com/inward/record.url?scp=85061508674&partnerID=8YFLogxK
U2 - 10.1093/sleep/zsy228
DO - 10.1093/sleep/zsy228
M3 - Article
VL - 42
JO - Sleep
T2 - Sleep
JF - Sleep
SN - 0161-8105
IS - 2
ER -