Impaired social functioning in children with narcolepsy

Laury Quaedackers; Merel M. van Gilst; Petra van Mierlo; Gert-Jan Lammers; Karlien Dhondt; Pauline Amesz; Els Peeters; Danielle Hendriks; Nele Vandenbussche; Sigrid Pillen; Sebastiaan Overeem

doi:10.1093/sleep/zsy228

Impaired social functioning in children with narcolepsy

Laury Quaedackers (Corresponding author), Merel M. van Gilst, Petra van Mierlo, Gert-Jan Lammers, Karlien Dhondt, Pauline Amesz, Els Peeters, Danielle Hendriks, Nele Vandenbussche, Sigrid Pillen, Sebastiaan Overeem

Research output: Contribution to journal › Article › Academic › peer-review

23 Citations (Scopus)

Abstract

Study Objectives To explore impairments in social functioning in children with narcolepsy compared to healthy children. Methods Parents of 53 pediatric patients with narcolepsy type 1 and 64 matched healthy children completed the Social Responsiveness Scale (SRS) and the Child Behavior Checklist 6-18 (CBCL 6-18). Results Patients scored significantly higher on the total score of the SRS (median 56, interquartile range [IQR] 23.5) compared to controls (median 44.5, IQR 8.5, U = 797.0, p < 0.001). Patients also scored higher on the sum of the CBCL 6-18 subscales indicative of social functioning (Withdrawn/Depressed, Social Problems, and Thought Problems; median 183, IQR 30.5) compared to controls (median 155, IQR 13, U = 500.0, p < 0.001). A total of 24 patients (45.3%) reported at least mild-to-moderate difficulties in social functioning compared to seven controls (10.9%, χ 2 = 17.165, p < 0.001). Eleven patients (20.8%) and only one control (1.6%) had T scores above 75, which points to severely impaired social functioning (χ 2 = 11.602, p = 0.001). Within the patient group, girls reported mild-to-moderate difficulties in social functioning significantly more often compared to boys on the SRS (77.8% versus 28.6%, χ 2 = 17.560, p < 0.001). Conclusions Impaired social functioning is common in children with narcolepsy type 1, especially in girls. Questionnaires such as the SRS and the CBCL 6-18 may help in early detection of social problems in pediatric narcolepsy. Recognition of these problems could be valuable in the management of young people with narcolepsy.

Original language	English
Article number	zsy228
Journal	Sleep
Volume	42
Issue number	2
Early online date	23 Nov 2018
DOIs	https://doi.org/10.1093/sleep/zsy228
Publication status	Published - 1 Feb 2019

Funding

This work was performed with the IMPULS framework of the Eindhoven MedTech Innovation Center (E/MTIC, a collaboration between Center for Sleep Medicine, Kempenhaeghe, Eindhoven University of Technology, and Philips Research). We wish to thank all of the patients, control participants and their parents who volunteered for this research. This was not an industry supported study. S.O. was supported by a VIDI grant from the Dutch Organization for Scientific Research (NWO grant no. 016.116.371). S.O. received a nonrestricted research grant on narcolepsy from UCB Pharma, not related to the present study. Conflict of interest statement. None declared.

Keywords

behavior
Child Behavior Checklist
narcolepsy
NT1
pediatric
social
Social Responsiveness Scale

Access to Document

10.1093/sleep/zsy228

Cite this

@article{33d345b1b8154b7dba7f00ef1691dbdd,

title = "Impaired social functioning in children with narcolepsy",

abstract = "Study Objectives To explore impairments in social functioning in children with narcolepsy compared to healthy children. Methods Parents of 53 pediatric patients with narcolepsy type 1 and 64 matched healthy children completed the Social Responsiveness Scale (SRS) and the Child Behavior Checklist 6-18 (CBCL 6-18). Results Patients scored significantly higher on the total score of the SRS (median 56, interquartile range [IQR] 23.5) compared to controls (median 44.5, IQR 8.5, U = 797.0, p < 0.001). Patients also scored higher on the sum of the CBCL 6-18 subscales indicative of social functioning (Withdrawn/Depressed, Social Problems, and Thought Problems; median 183, IQR 30.5) compared to controls (median 155, IQR 13, U = 500.0, p < 0.001). A total of 24 patients (45.3%) reported at least mild-to-moderate difficulties in social functioning compared to seven controls (10.9%, χ 2 = 17.165, p < 0.001). Eleven patients (20.8%) and only one control (1.6%) had T scores above 75, which points to severely impaired social functioning (χ 2 = 11.602, p = 0.001). Within the patient group, girls reported mild-to-moderate difficulties in social functioning significantly more often compared to boys on the SRS (77.8% versus 28.6%, χ 2 = 17.560, p < 0.001). Conclusions Impaired social functioning is common in children with narcolepsy type 1, especially in girls. Questionnaires such as the SRS and the CBCL 6-18 may help in early detection of social problems in pediatric narcolepsy. Recognition of these problems could be valuable in the management of young people with narcolepsy.",

keywords = "behavior, Child Behavior Checklist, narcolepsy, NT1, pediatric, social, Social Responsiveness Scale",

author = "Laury Quaedackers and {van Gilst}, {Merel M.} and {van Mierlo}, Petra and Gert-Jan Lammers and Karlien Dhondt and Pauline Amesz and Els Peeters and Danielle Hendriks and Nele Vandenbussche and Sigrid Pillen and Sebastiaan Overeem",

year = "2019",

month = feb,

day = "1",

doi = "10.1093/sleep/zsy228",

language = "English",

volume = "42",

journal = "Sleep",

issn = "0161-8105",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - Impaired social functioning in children with narcolepsy

AU - Quaedackers, Laury

AU - van Gilst, Merel M.

AU - van Mierlo, Petra

AU - Lammers, Gert-Jan

AU - Dhondt, Karlien

AU - Amesz, Pauline

AU - Peeters, Els

AU - Hendriks, Danielle

AU - Vandenbussche, Nele

AU - Pillen, Sigrid

AU - Overeem, Sebastiaan

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Study Objectives To explore impairments in social functioning in children with narcolepsy compared to healthy children. Methods Parents of 53 pediatric patients with narcolepsy type 1 and 64 matched healthy children completed the Social Responsiveness Scale (SRS) and the Child Behavior Checklist 6-18 (CBCL 6-18). Results Patients scored significantly higher on the total score of the SRS (median 56, interquartile range [IQR] 23.5) compared to controls (median 44.5, IQR 8.5, U = 797.0, p < 0.001). Patients also scored higher on the sum of the CBCL 6-18 subscales indicative of social functioning (Withdrawn/Depressed, Social Problems, and Thought Problems; median 183, IQR 30.5) compared to controls (median 155, IQR 13, U = 500.0, p < 0.001). A total of 24 patients (45.3%) reported at least mild-to-moderate difficulties in social functioning compared to seven controls (10.9%, χ 2 = 17.165, p < 0.001). Eleven patients (20.8%) and only one control (1.6%) had T scores above 75, which points to severely impaired social functioning (χ 2 = 11.602, p = 0.001). Within the patient group, girls reported mild-to-moderate difficulties in social functioning significantly more often compared to boys on the SRS (77.8% versus 28.6%, χ 2 = 17.560, p < 0.001). Conclusions Impaired social functioning is common in children with narcolepsy type 1, especially in girls. Questionnaires such as the SRS and the CBCL 6-18 may help in early detection of social problems in pediatric narcolepsy. Recognition of these problems could be valuable in the management of young people with narcolepsy.

AB - Study Objectives To explore impairments in social functioning in children with narcolepsy compared to healthy children. Methods Parents of 53 pediatric patients with narcolepsy type 1 and 64 matched healthy children completed the Social Responsiveness Scale (SRS) and the Child Behavior Checklist 6-18 (CBCL 6-18). Results Patients scored significantly higher on the total score of the SRS (median 56, interquartile range [IQR] 23.5) compared to controls (median 44.5, IQR 8.5, U = 797.0, p < 0.001). Patients also scored higher on the sum of the CBCL 6-18 subscales indicative of social functioning (Withdrawn/Depressed, Social Problems, and Thought Problems; median 183, IQR 30.5) compared to controls (median 155, IQR 13, U = 500.0, p < 0.001). A total of 24 patients (45.3%) reported at least mild-to-moderate difficulties in social functioning compared to seven controls (10.9%, χ 2 = 17.165, p < 0.001). Eleven patients (20.8%) and only one control (1.6%) had T scores above 75, which points to severely impaired social functioning (χ 2 = 11.602, p = 0.001). Within the patient group, girls reported mild-to-moderate difficulties in social functioning significantly more often compared to boys on the SRS (77.8% versus 28.6%, χ 2 = 17.560, p < 0.001). Conclusions Impaired social functioning is common in children with narcolepsy type 1, especially in girls. Questionnaires such as the SRS and the CBCL 6-18 may help in early detection of social problems in pediatric narcolepsy. Recognition of these problems could be valuable in the management of young people with narcolepsy.

KW - behavior

KW - Child Behavior Checklist

KW - narcolepsy

KW - NT1

KW - pediatric

KW - social

KW - Social Responsiveness Scale

UR - http://www.scopus.com/inward/record.url?scp=85061508674&partnerID=8YFLogxK

U2 - 10.1093/sleep/zsy228

DO - 10.1093/sleep/zsy228

M3 - Article

C2 - 30476304

SN - 0161-8105

VL - 42

JO - Sleep

JF - Sleep

IS - 2

M1 - zsy228

ER -

Impaired social functioning in children with narcolepsy

Abstract

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Sleep Medicine

Cite this

Impaired social functioning in children with narcolepsy

Abstract

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Research areas

Sleep Medicine

Cite this