Imidazoles as hypnotic agents. II. The synthesis of certain 5,6-disubstituted 8-oxo-8H-imidazo[5,1-c] [1,4] oxazines

E.F. Godefroi, C.A.M. Van der Eycken, P.A.J. Janssen

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

cf. 62, 10428d. The synthesis of DL-1-(a-carboxybenzyl)imidazole-5-carboxylic acid is described. This compd. reacts with acetic and propionic anhydride to give enol lactones Ia and b, resp. Redn. of the corresponding oxo acids IIa and b with sodium borohydride, gives, upon heating, lactones IIIa and b.
Original languageEnglish
Pages (from-to)806-808
Number of pages3
JournalJournal of Organic Chemistry
Volume31
Issue number3
DOIs
Publication statusPublished - 1966

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