Imaging PPG for In Vivo Human Tissue Perfusion Assessment during Surgery

Marco Lai; Stefan D. van der Stel; Harald C. Groen; Mark van Gastel; Koert F.D. Kuhlmann; Theo J.M. Ruers; Benno H.W. Hendriks

doi:10.3390/jimaging8040094

Imaging PPG for In Vivo Human Tissue Perfusion Assessment during Surgery

Marco Lai
, Stefan D. van der Stel (Corresponding author)
, Harald C. Groen
, Mark van Gastel
, Koert F.D. Kuhlmann
, Theo J.M. Ruers
, Benno H.W. Hendriks

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

160 Downloads (Pure)

Abstract

Surgical excision is the golden standard for treatment of intestinal tumors. In this surgical procedure, inadequate perfusion of the anastomosis can lead to postoperative complications, such as anastomotic leakages. Imaging photoplethysmography (iPPG) can potentially provide objective and real-time feedback of the perfusion status of tissues. This feasibility study aims to evaluate an iPPG acquisition system during intestinal surgeries to detect the perfusion levels of the microvasculature tissue bed in different perfusion conditions. This feasibility study assesses three patients that underwent resection of a portion of the small intestine. Data was acquired from fully perfused, non-perfused and anastomosis parts of the intestine during different phases of the surgical procedure. Strategies for limiting motion and noise during acquisition were implemented. iPPG perfusion maps were successfully extracted from the intestine microvasculature, demonstrating that iPPG can be successfully used for detecting perturbations and perfusion changes in intestinal tissues during surgery. This study provides proof of concept for iPPG to detect changes in organ perfusion levels.

Original language	English
Article number	94
Number of pages	16
Journal	Journal of Imaging
Volume	8
Issue number	4
DOIs	https://doi.org/10.3390/jimaging8040094
Publication status	Published - Apr 2022

Bibliographical note

Funding Information:
Funding: The author Marco Lai (M Lai) has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No.: 721766 (FBI). Website: https://ec.europa.eu/programmes/horizon2020/en, accessed on 20 February 2022. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Funding

Funding: The author Marco Lai (M Lai) has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No.: 721766 (FBI). Website: https://ec.europa.eu/programmes/horizon2020/en, accessed on 20 February 2022. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Keywords

imaging photoplethysmography
intestinal surgery
intraoperative perfusion assessment
iPPG
optical technology

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title = "Imaging PPG for In Vivo Human Tissue Perfusion Assessment during Surgery",

abstract = "Surgical excision is the golden standard for treatment of intestinal tumors. In this surgical procedure, inadequate perfusion of the anastomosis can lead to postoperative complications, such as anastomotic leakages. Imaging photoplethysmography (iPPG) can potentially provide objective and real-time feedback of the perfusion status of tissues. This feasibility study aims to evaluate an iPPG acquisition system during intestinal surgeries to detect the perfusion levels of the microvasculature tissue bed in different perfusion conditions. This feasibility study assesses three patients that underwent resection of a portion of the small intestine. Data was acquired from fully perfused, non-perfused and anastomosis parts of the intestine during different phases of the surgical procedure. Strategies for limiting motion and noise during acquisition were implemented. iPPG perfusion maps were successfully extracted from the intestine microvasculature, demonstrating that iPPG can be successfully used for detecting perturbations and perfusion changes in intestinal tissues during surgery. This study provides proof of concept for iPPG to detect changes in organ perfusion levels.",

keywords = "imaging photoplethysmography, intestinal surgery, intraoperative perfusion assessment, iPPG, optical technology",

author = "Marco Lai and \{van der Stel\}, \{Stefan D.\} and Groen, \{Harald C.\} and \{van Gastel\}, Mark and Kuhlmann, \{Koert F.D.\} and Ruers, \{Theo J.M.\} and Hendriks, \{Benno H.W.\}",

note = "Funding Information: Funding: The author Marco Lai (M Lai) has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation program under the Marie Sk{\l}odowska-Curie grant agreement No.: 721766 (FBI). Website: https://ec.europa.eu/programmes/horizon2020/en, accessed on 20 February 2022. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ",

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doi = "10.3390/jimaging8040094",

language = "English",

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AU - Kuhlmann, Koert F.D.

AU - Ruers, Theo J.M.

AU - Hendriks, Benno H.W.

N1 - Funding Information: Funding: The author Marco Lai (M Lai) has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No.: 721766 (FBI). Website: https://ec.europa.eu/programmes/horizon2020/en, accessed on 20 February 2022. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

PY - 2022/4

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N2 - Surgical excision is the golden standard for treatment of intestinal tumors. In this surgical procedure, inadequate perfusion of the anastomosis can lead to postoperative complications, such as anastomotic leakages. Imaging photoplethysmography (iPPG) can potentially provide objective and real-time feedback of the perfusion status of tissues. This feasibility study aims to evaluate an iPPG acquisition system during intestinal surgeries to detect the perfusion levels of the microvasculature tissue bed in different perfusion conditions. This feasibility study assesses three patients that underwent resection of a portion of the small intestine. Data was acquired from fully perfused, non-perfused and anastomosis parts of the intestine during different phases of the surgical procedure. Strategies for limiting motion and noise during acquisition were implemented. iPPG perfusion maps were successfully extracted from the intestine microvasculature, demonstrating that iPPG can be successfully used for detecting perturbations and perfusion changes in intestinal tissues during surgery. This study provides proof of concept for iPPG to detect changes in organ perfusion levels.

AB - Surgical excision is the golden standard for treatment of intestinal tumors. In this surgical procedure, inadequate perfusion of the anastomosis can lead to postoperative complications, such as anastomotic leakages. Imaging photoplethysmography (iPPG) can potentially provide objective and real-time feedback of the perfusion status of tissues. This feasibility study aims to evaluate an iPPG acquisition system during intestinal surgeries to detect the perfusion levels of the microvasculature tissue bed in different perfusion conditions. This feasibility study assesses three patients that underwent resection of a portion of the small intestine. Data was acquired from fully perfused, non-perfused and anastomosis parts of the intestine during different phases of the surgical procedure. Strategies for limiting motion and noise during acquisition were implemented. iPPG perfusion maps were successfully extracted from the intestine microvasculature, demonstrating that iPPG can be successfully used for detecting perturbations and perfusion changes in intestinal tissues during surgery. This study provides proof of concept for iPPG to detect changes in organ perfusion levels.

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KW - intraoperative perfusion assessment

KW - iPPG

KW - optical technology

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Imaging PPG for In Vivo Human Tissue Perfusion Assessment during Surgery

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