Identification of a switching model of calcium cycling in isolated rat hearts

J. Op den Buijs, A.L. Juloski, T. Ivanics, L. Ligeti, G.J. Vusse, van der, N.A.W. Riel, van

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)

Abstract

So far, the processes involved in regulation of intracellular calcium (Ca/sub i//sup 2+/) in cardiomyocytes have been mainly studied through biochemical and isolated cell analysis. Here, we present a novel technique to model and identify cardiac Ca/sub i//sup 2+/-cycling under physiologically relevant conditions in the intact beating heart. Ca/sub i//sup 2+/ was measured using fluorescence techniques in ex vivo perfused rat hearts. For analysis, we developed a parametric mathematical model, switching between active and inactive calcium release. The kinetic parameters of the two submodes of the model were computed using a recently developed technique from hybrid system identification. Application of the method to control and isoproterenol-stimulated hearts resulted in parameter values within a physiologically reliable range.
Original languageEnglish
Title of host publicationEMBC : Engineering in medicine and biology : annual international conference : proceedings, 26th, September 1-5, 2004
Place of PublicationPiscataway, NJ, USA
PublisherInstitute of Electrical and Electronics Engineers
Pages841-844
ISBN (Print)0-7803-8439-3
DOIs
Publication statusPublished - 2004
Event26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2004) - San Francisco, United States
Duration: 1 Sep 20045 Sep 2004
Conference number: 26

Conference

Conference26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2004)
Abbreviated titleEMBC 2004
CountryUnited States
CitySan Francisco
Period1/09/045/09/04

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