Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenases

F. Kaschani; J. Clerc; D. Krahn; D. Bier; T.N. Hong; C. Ottmann; S. Niessen; T. Colby; R.A.L. Hoorn, van der; M. Kaiser

doi:10.1002/anie.201107276

Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenases

F. Kaschani
, J. Clerc
, D. Krahn
, D. Bier
, T.N. Hong
, C. Ottmann
, S. Niessen
, T. Colby
, R.A.L. Hoorn, van der
, M. Kaiser

Chemical Biology

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

2 Downloads (Pure)

Abstract

Exceptionally specific: The natural-product-like structural complexity of a bicyclic hydantoin was exploited to generate the novel, highly specific activity-based profiling probe (ABPP) Mrl-Rh (Rh=rhodamine; see picture) for glyceraldehyde 3-phosphate dehydrogenases. This probe can be used to investigate activity changes of this enzyme class during plant–pathogen interactions.

Original language	English
Pages (from-to)	5230-5233
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	21
DOIs	https://doi.org/10.1002/anie.201107276
Publication status	Published - 2012

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title = "Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenases",

abstract = "Exceptionally specific: The natural-product-like structural complexity of a bicyclic hydantoin was exploited to generate the novel, highly specific activity-based profiling probe (ABPP) Mrl-Rh (Rh=rhodamine; see picture) for glyceraldehyde 3-phosphate dehydrogenases. This probe can be used to investigate activity changes of this enzyme class during plant–pathogen interactions.",

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AU - Kaschani, F.

AU - Clerc, J.

AU - Krahn, D.

AU - Bier, D.

AU - Hong, T.N.

AU - Ottmann, C.

AU - Niessen, S.

AU - Colby, T.

AU - Hoorn, van der, R.A.L.

AU - Kaiser, M.

PY - 2012

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AB - Exceptionally specific: The natural-product-like structural complexity of a bicyclic hydantoin was exploited to generate the novel, highly specific activity-based profiling probe (ABPP) Mrl-Rh (Rh=rhodamine; see picture) for glyceraldehyde 3-phosphate dehydrogenases. This probe can be used to investigate activity changes of this enzyme class during plant–pathogen interactions.

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DO - 10.1002/anie.201107276

M3 - Article

C2 - 22489074

SN - 0570-0833

VL - 51

SP - 5230

EP - 5233

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 21

ER -

Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenases

Abstract

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