Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenases

F. Kaschani, J. Clerc, D. Krahn, D. Bier, T.N. Hong, C. Ottmann, S. Niessen, T. Colby, R.A.L. Hoorn, van der, M. Kaiser

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Abstract

Exceptionally specific: The natural-product-like structural complexity of a bicyclic hydantoin was exploited to generate the novel, highly specific activity-based profiling probe (ABPP) Mrl-Rh (Rh=rhodamine; see picture) for glyceraldehyde 3-phosphate dehydrogenases. This probe can be used to investigate activity changes of this enzyme class during plant–pathogen interactions.
Original languageEnglish
Pages (from-to)5230-5233
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number21
DOIs
Publication statusPublished - 2012

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