TY - JOUR
T1 - Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenases
AU - Kaschani, F.
AU - Clerc, J.
AU - Krahn, D.
AU - Bier, D.
AU - Hong, T.N.
AU - Ottmann, C.
AU - Niessen, S.
AU - Colby, T.
AU - Hoorn, van der, R.A.L.
AU - Kaiser, M.
PY - 2012
Y1 - 2012
N2 - Exceptionally specific: The natural-product-like structural complexity of a bicyclic hydantoin was exploited to generate the novel, highly specific activity-based profiling probe (ABPP) Mrl-Rh (Rh=rhodamine; see picture) for glyceraldehyde 3-phosphate dehydrogenases. This probe can be used to investigate activity changes of this enzyme class during plant–pathogen interactions.
AB - Exceptionally specific: The natural-product-like structural complexity of a bicyclic hydantoin was exploited to generate the novel, highly specific activity-based profiling probe (ABPP) Mrl-Rh (Rh=rhodamine; see picture) for glyceraldehyde 3-phosphate dehydrogenases. This probe can be used to investigate activity changes of this enzyme class during plant–pathogen interactions.
U2 - 10.1002/anie.201107276
DO - 10.1002/anie.201107276
M3 - Article
C2 - 22489074
SN - 0570-0833
VL - 51
SP - 5230
EP - 5233
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 21
ER -