Identifiability analysis of the standard pharmacokinetic models in DCE MR imaging of tumours

R.G.P. Lopata; N.A.W. Riel, van

doi:10.1109/IEMBS.2004.1403341

Identifiability analysis of the standard pharmacokinetic models in DCE MR imaging of tumours

R.G.P. Lopata, N.A.W. Riel, van

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

The usage of dynamic contrast-enhanced MRI (DCE-MRI) as a clinical tool is still widely assessed. Application of the standard pharmacokinetic models to obtain physiologically relevant parameter values using DCE-MRI in tumours is not trivial, when the temporal resolution is low. Mathematical analysis and analysis by simulation of the identifiability for the generalized and extended Kety models was executed. Parameter estimation was executed using synthetic data sets and maximum likelihood estimation (MLE). The influence of temporal resolution was examined. The generalized and extended Kety model showed a large bias in the parameter estimates (10-120%) for sampling times >4 s, although the estimated variance was relatively low (

Original language	English
Title of host publication	Proc. 26th Conf. of the IEEE Engineering in Medicine and Biology Society
Pages	1040-1043
DOIs	https://doi.org/10.1109/IEMBS.2004.1403341
Publication status	Published - 2004
Event	26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, United States Duration: 1 Sept 2004 → 5 Sept 2004 Conference number: 26

Conference

Conference	26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004
Abbreviated title	EMBC 2004
Country/Territory	United States
City	San Francisco
Period	1/09/04 → 5/09/04

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10.1109/IEMBS.2004.1403341

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title = "Identifiability analysis of the standard pharmacokinetic models in DCE MR imaging of tumours",

abstract = "The usage of dynamic contrast-enhanced MRI (DCE-MRI) as a clinical tool is still widely assessed. Application of the standard pharmacokinetic models to obtain physiologically relevant parameter values using DCE-MRI in tumours is not trivial, when the temporal resolution is low. Mathematical analysis and analysis by simulation of the identifiability for the generalized and extended Kety models was executed. Parameter estimation was executed using synthetic data sets and maximum likelihood estimation (MLE). The influence of temporal resolution was examined. The generalized and extended Kety model showed a large bias in the parameter estimates (10-120\%) for sampling times >4 s, although the estimated variance was relatively low (",

author = "R.G.P. Lopata and \{Riel, van\}, N.A.W.",

year = "2004",

doi = "10.1109/IEMBS.2004.1403341",

language = "English",

isbn = "0-7803-8439-3",

pages = "1040--1043",

booktitle = "Proc. 26th Conf. of the IEEE Engineering in Medicine and Biology Society",

note = "26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004, EMBC 2004 ; Conference date: 01-09-2004 Through 05-09-2004",

}

Lopata, RGP & Riel, van, NAW 2004, Identifiability analysis of the standard pharmacokinetic models in DCE MR imaging of tumours. in Proc. 26th Conf. of the IEEE Engineering in Medicine and Biology Society. pp. 1040-1043, 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004, San Francisco, California, United States, 1/09/04. https://doi.org/10.1109/IEMBS.2004.1403341

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AU - Lopata, R.G.P.

AU - Riel, van, N.A.W.

N1 - Conference code: 26

PY - 2004

Y1 - 2004

N2 - The usage of dynamic contrast-enhanced MRI (DCE-MRI) as a clinical tool is still widely assessed. Application of the standard pharmacokinetic models to obtain physiologically relevant parameter values using DCE-MRI in tumours is not trivial, when the temporal resolution is low. Mathematical analysis and analysis by simulation of the identifiability for the generalized and extended Kety models was executed. Parameter estimation was executed using synthetic data sets and maximum likelihood estimation (MLE). The influence of temporal resolution was examined. The generalized and extended Kety model showed a large bias in the parameter estimates (10-120%) for sampling times >4 s, although the estimated variance was relatively low (

AB - The usage of dynamic contrast-enhanced MRI (DCE-MRI) as a clinical tool is still widely assessed. Application of the standard pharmacokinetic models to obtain physiologically relevant parameter values using DCE-MRI in tumours is not trivial, when the temporal resolution is low. Mathematical analysis and analysis by simulation of the identifiability for the generalized and extended Kety models was executed. Parameter estimation was executed using synthetic data sets and maximum likelihood estimation (MLE). The influence of temporal resolution was examined. The generalized and extended Kety model showed a large bias in the parameter estimates (10-120%) for sampling times >4 s, although the estimated variance was relatively low (

U2 - 10.1109/IEMBS.2004.1403341

DO - 10.1109/IEMBS.2004.1403341

M3 - Conference contribution

C2 - 17271860

SN - 0-7803-8439-3

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BT - Proc. 26th Conf. of the IEEE Engineering in Medicine and Biology Society

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Y2 - 1 September 2004 through 5 September 2004

ER -

Identifiability analysis of the standard pharmacokinetic models in DCE MR imaging of tumours

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