Identifiability analysis of the standard pharmacokinetic models in DCE MR imaging of tumours

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Abstract

The usage of dynamic contrast-enhanced MRI (DCE-MRI) as a clinical tool is still widely assessed. Application of the standard pharmacokinetic models to obtain physiologically relevant parameter values using DCE-MRI in tumours is not trivial, when the temporal resolution is low. Mathematical analysis and analysis by simulation of the identifiability for the generalized and extended Kety models was executed. Parameter estimation was executed using synthetic data sets and maximum likelihood estimation (MLE). The influence of temporal resolution was examined. The generalized and extended Kety model showed a large bias in the parameter estimates (10-120%) for sampling times >4 s, although the estimated variance was relatively low (
Original languageEnglish
Title of host publicationProc. 26th Conf. of the IEEE Engineering in Medicine and Biology Society
Pages1040-1043
DOIs
Publication statusPublished - 2004
Event26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2004) - San Francisco, United States
Duration: 1 Sep 20045 Sep 2004
Conference number: 26

Conference

Conference26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2004)
Abbreviated titleEMBC 2004
CountryUnited States
CitySan Francisco
Period1/09/045/09/04

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