Ictal autonomic changes as a tool for seizure detection: a systematic review

Anouk van Westrhenen, Thomas De Cooman, Richard H.C. Lazeron, Sabine Van Huffel, Roland D. Thijs (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

Purpose: Adequate epileptic seizure detection may have the potential to minimize seizure-related complications and improve treatment evaluation. Autonomic changes often precede ictal electroencephalographic discharges and therefore provide a promising tool for timely seizure detection. We reviewed the literature for seizure detection algorithms using autonomic nervous system parameters. Methods: The PubMed and Embase databases were systematically searched for original human studies that validate an algorithm for automatic seizure detection based on autonomic function alterations. Studies on neonates only and pilot studies without performance data were excluded. Algorithm performance was compared for studies with a similar design (retrospective vs. prospective) reporting both sensitivity and false alarm rate (FAR). Quality assessment was performed using QUADAS-2 and recently reported quality standards on reporting seizure detection algorithms. Results: Twenty-one out of 638 studies were included in the analysis. Fifteen studies presented a single-modality algorithm based on heart rate variability (n = 10), heart rate (n = 4), or QRS morphology (n = 1), while six studies assessed multimodal algorithms using various combinations of HR, corrected QT interval, oxygen saturation, electrodermal activity, and accelerometry. Most studies had small sample sizes and a short follow-up period. Only two studies performed a prospective validation. A tendency for a lower FAR was found for retrospectively validated algorithms using multimodal autonomic parameters compared to those using single modalities (mean sensitivity per participant 71–100% vs. 64–96%, and mean FAR per participant 0.0–2.4/h vs. 0.7–5.4/h). Conclusions: The overall quality of studies on seizure detection using autonomic parameters is low. Unimodal autonomic algorithms cannot reach acceptable performance as false alarm rates are still too high. Larger prospective studies are needed to validate multimodal automatic seizure detection.

LanguageEnglish
Pages161-181
JournalClinical Autonomic Research
Volume29
Issue number2
DOIs
StatePublished - Apr 2019

Fingerprint

Seizures
Stroke
Heart Rate
Accelerometry
Autonomic Nervous System
PubMed
Sample Size
Epilepsy
Databases
Prospective Studies
Oxygen

Keywords

  • Algorithm(s)
  • Automatic seizure detection
  • Autonomic function(s)
  • Autonomic parameter(s)
  • Epilepsy
  • SUDEP

Cite this

van Westrhenen, Anouk ; De Cooman, Thomas ; Lazeron, Richard H.C. ; Van Huffel, Sabine ; Thijs, Roland D./ Ictal autonomic changes as a tool for seizure detection : a systematic review. In: Clinical Autonomic Research. 2019 ; Vol. 29, No. 2. pp. 161-181
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abstract = "Purpose: Adequate epileptic seizure detection may have the potential to minimize seizure-related complications and improve treatment evaluation. Autonomic changes often precede ictal electroencephalographic discharges and therefore provide a promising tool for timely seizure detection. We reviewed the literature for seizure detection algorithms using autonomic nervous system parameters. Methods: The PubMed and Embase databases were systematically searched for original human studies that validate an algorithm for automatic seizure detection based on autonomic function alterations. Studies on neonates only and pilot studies without performance data were excluded. Algorithm performance was compared for studies with a similar design (retrospective vs. prospective) reporting both sensitivity and false alarm rate (FAR). Quality assessment was performed using QUADAS-2 and recently reported quality standards on reporting seizure detection algorithms. Results: Twenty-one out of 638 studies were included in the analysis. Fifteen studies presented a single-modality algorithm based on heart rate variability (n = 10), heart rate (n = 4), or QRS morphology (n = 1), while six studies assessed multimodal algorithms using various combinations of HR, corrected QT interval, oxygen saturation, electrodermal activity, and accelerometry. Most studies had small sample sizes and a short follow-up period. Only two studies performed a prospective validation. A tendency for a lower FAR was found for retrospectively validated algorithms using multimodal autonomic parameters compared to those using single modalities (mean sensitivity per participant 71–100{\%} vs. 64–96{\%}, and mean FAR per participant 0.0–2.4/h vs. 0.7–5.4/h). Conclusions: The overall quality of studies on seizure detection using autonomic parameters is low. Unimodal autonomic algorithms cannot reach acceptable performance as false alarm rates are still too high. Larger prospective studies are needed to validate multimodal automatic seizure detection.",
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Ictal autonomic changes as a tool for seizure detection : a systematic review. / van Westrhenen, Anouk; De Cooman, Thomas; Lazeron, Richard H.C.; Van Huffel, Sabine; Thijs, Roland D. (Corresponding author).

In: Clinical Autonomic Research, Vol. 29, No. 2, 04.2019, p. 161-181.

Research output: Contribution to journalArticleAcademicpeer-review

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