Hypoxia affects mesenchymal stromal cell osteogenic differentiation and angiogenic factor expression

E. Potier, E. Ferreira, R. Andriamanalijaona, J.P. Pujol, K. Oudina, D. Logeart-Avramoglou, H. Petite

Research output: Contribution to journalArticleAcademicpeer-review

213 Citations (Scopus)

Abstract

Mesenchymal stromal cells (MSCs) seeded onto biocompatible scaffolds have been proposed for repairing bone defects. When transplanted in vivo, MSCs (expanded in vitro in 21% O(2)) undergo temporary oxygen deprivation due to the lack of pre-existing blood vessels within these scaffolds. In the present study, the effects of temporary (48 h) exposure to hypoxia (
Original languageEnglish
Pages (from-to)1078-87
JournalBone
Volume40
Issue number4
DOIs
Publication statusPublished - 2007

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