Hyperthermia by electromagnetic fields to enhanced clinical results in oncology

Gerard C. van Rhoon; Maarten M. Paulides; Jeannette M.L. van Holthe; Martine Franckena

doi:10.1109/EMBC.2016.7590714

Hyperthermia by electromagnetic fields to enhanced clinical results in oncology

Gerard C. van Rhoon, Maarten M. Paulides, Jeannette M.L. van Holthe, Martine Franckena

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

5 Citations (Scopus)

Abstract

Confining treatment to the tumor to improve therapeutic outcome and reduce toxicity, is a hot issue in cancer research. Hyperthermia is recognized as a strong sensitizer for radiotherapy and chemotherapy enhancing tumor control without increasing toxicity. Today's electromagnetic hyperthermia systems heat large tissue volumes with limited ability to selectively heat the tumor. Fortunately, tremendous improvements in 3-dimensional electromagnetic & temperature modelling provide an exciting opportunity to design advanced multi-element electromagnetic applicator systems. Together with feedback control using MR non-invasive thermometry and smart E-field sensors, this paves the way for selective tumor heating and potentially prescription of a thermal dose. A technological advanced hyperthermia system, with guaranteed delivery of high quality hyperthermia lowers the threshold for newcomers to apply hyperthermia. Combined with recent proof that hyperthermia blocks DNA repair and new, exciting, ways for controlled drug delivery using temperature sensitive liposome encapsulated drugs, this is expected to increase interest of the medical community in hyperthermia.

Original language	English
Title of host publication	2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) : 16-20 Aug. 2016.
Place of Publication	Piscataway
Publisher	Institute of Electrical and Electronics Engineers
Pages	359-362
Number of pages	4
ISBN (Electronic)	978-1-4577-0220-4
ISBN (Print)	978-1-4577-0219-8
DOIs	https://doi.org/10.1109/EMBC.2016.7590714
Publication status	Published - Aug 2016
Externally published	Yes
Event	38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Disney’s Contemporary Resort , Orlando, United States Duration: 16 Aug 2016 → 20 Aug 2016 Conference number: 38 http://embc.embs.org/2016/

Conference

Conference	38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
Abbreviated title	EMBC 2016
Country/Territory	United States
City	Orlando
Period	16/08/16 → 20/08/16
Internet address	http://embc.embs.org/2016/

Keywords

Clinical Trials as Topic
Electromagnetic Fields
Humans
Hyperthermia, Induced/methods
Microwaves
Neoplasms/therapy
Temperature

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/EMBC.2016.7590714

Cite this

van Rhoon, G. C., Paulides, M. M., van Holthe, J. M. L., & Franckena, M. (2016). Hyperthermia by electromagnetic fields to enhanced clinical results in oncology. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) : 16-20 Aug. 2016. (pp. 359-362). Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/EMBC.2016.7590714

van Rhoon, Gerard C. ; Paulides, Maarten M. ; van Holthe, Jeannette M.L. et al. / Hyperthermia by electromagnetic fields to enhanced clinical results in oncology. 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) : 16-20 Aug. 2016. . Piscataway : Institute of Electrical and Electronics Engineers, 2016. pp. 359-362

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title = "Hyperthermia by electromagnetic fields to enhanced clinical results in oncology",

abstract = "Confining treatment to the tumor to improve therapeutic outcome and reduce toxicity, is a hot issue in cancer research. Hyperthermia is recognized as a strong sensitizer for radiotherapy and chemotherapy enhancing tumor control without increasing toxicity. Today's electromagnetic hyperthermia systems heat large tissue volumes with limited ability to selectively heat the tumor. Fortunately, tremendous improvements in 3-dimensional electromagnetic & temperature modelling provide an exciting opportunity to design advanced multi-element electromagnetic applicator systems. Together with feedback control using MR non-invasive thermometry and smart E-field sensors, this paves the way for selective tumor heating and potentially prescription of a thermal dose. A technological advanced hyperthermia system, with guaranteed delivery of high quality hyperthermia lowers the threshold for newcomers to apply hyperthermia. Combined with recent proof that hyperthermia blocks DNA repair and new, exciting, ways for controlled drug delivery using temperature sensitive liposome encapsulated drugs, this is expected to increase interest of the medical community in hyperthermia.",

keywords = "Clinical Trials as Topic, Electromagnetic Fields, Humans, Hyperthermia, Induced/methods, Microwaves, Neoplasms/therapy, Temperature",

author = "{van Rhoon}, {Gerard C.} and Paulides, {Maarten M.} and {van Holthe}, {Jeannette M.L.} and Martine Franckena",

year = "2016",

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doi = "10.1109/EMBC.2016.7590714",

language = "English",

isbn = "978-1-4577-0219-8",

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publisher = "Institute of Electrical and Electronics Engineers",

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van Rhoon, GC, Paulides, MM, van Holthe, JML & Franckena, M 2016, Hyperthermia by electromagnetic fields to enhanced clinical results in oncology. in 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) : 16-20 Aug. 2016. . Institute of Electrical and Electronics Engineers, Piscataway, pp. 359-362, 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, Florida, United States, 16/08/16. https://doi.org/10.1109/EMBC.2016.7590714

Hyperthermia by electromagnetic fields to enhanced clinical results in oncology. / van Rhoon, Gerard C.; Paulides, Maarten M.; van Holthe, Jeannette M.L. et al.
2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) : 16-20 Aug. 2016. . Piscataway: Institute of Electrical and Electronics Engineers, 2016. p. 359-362.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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AU - van Rhoon, Gerard C.

AU - Paulides, Maarten M.

AU - van Holthe, Jeannette M.L.

AU - Franckena, Martine

N1 - Conference code: 38

PY - 2016/8

Y1 - 2016/8

N2 - Confining treatment to the tumor to improve therapeutic outcome and reduce toxicity, is a hot issue in cancer research. Hyperthermia is recognized as a strong sensitizer for radiotherapy and chemotherapy enhancing tumor control without increasing toxicity. Today's electromagnetic hyperthermia systems heat large tissue volumes with limited ability to selectively heat the tumor. Fortunately, tremendous improvements in 3-dimensional electromagnetic & temperature modelling provide an exciting opportunity to design advanced multi-element electromagnetic applicator systems. Together with feedback control using MR non-invasive thermometry and smart E-field sensors, this paves the way for selective tumor heating and potentially prescription of a thermal dose. A technological advanced hyperthermia system, with guaranteed delivery of high quality hyperthermia lowers the threshold for newcomers to apply hyperthermia. Combined with recent proof that hyperthermia blocks DNA repair and new, exciting, ways for controlled drug delivery using temperature sensitive liposome encapsulated drugs, this is expected to increase interest of the medical community in hyperthermia.

AB - Confining treatment to the tumor to improve therapeutic outcome and reduce toxicity, is a hot issue in cancer research. Hyperthermia is recognized as a strong sensitizer for radiotherapy and chemotherapy enhancing tumor control without increasing toxicity. Today's electromagnetic hyperthermia systems heat large tissue volumes with limited ability to selectively heat the tumor. Fortunately, tremendous improvements in 3-dimensional electromagnetic & temperature modelling provide an exciting opportunity to design advanced multi-element electromagnetic applicator systems. Together with feedback control using MR non-invasive thermometry and smart E-field sensors, this paves the way for selective tumor heating and potentially prescription of a thermal dose. A technological advanced hyperthermia system, with guaranteed delivery of high quality hyperthermia lowers the threshold for newcomers to apply hyperthermia. Combined with recent proof that hyperthermia blocks DNA repair and new, exciting, ways for controlled drug delivery using temperature sensitive liposome encapsulated drugs, this is expected to increase interest of the medical community in hyperthermia.

KW - Clinical Trials as Topic

KW - Electromagnetic Fields

KW - Humans

KW - Hyperthermia, Induced/methods

KW - Microwaves

KW - Neoplasms/therapy

KW - Temperature

U2 - 10.1109/EMBC.2016.7590714

DO - 10.1109/EMBC.2016.7590714

M3 - Conference contribution

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SN - 978-1-4577-0219-8

SP - 359

EP - 362

BT - 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) : 16-20 Aug. 2016.

PB - Institute of Electrical and Electronics Engineers

CY - Piscataway

T2 - 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016

Y2 - 16 August 2016 through 20 August 2016

ER -

van Rhoon GC, Paulides MM, van Holthe JML, Franckena M. Hyperthermia by electromagnetic fields to enhanced clinical results in oncology. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) : 16-20 Aug. 2016. . Piscataway: Institute of Electrical and Electronics Engineers. 2016. p. 359-362 doi: 10.1109/EMBC.2016.7590714

Hyperthermia by electromagnetic fields to enhanced clinical results in oncology

Abstract

Conference

Keywords

UN SDGs

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