Hyperthermia by electromagnetic fields to enhanced clinical results in oncology

Gerard C. van Rhoon, Maarten M. Paulides, Jeannette M.L. van Holthe, Martine Franckena

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

4 Citations (Scopus)

Abstract

Confining treatment to the tumor to improve therapeutic outcome and reduce toxicity, is a hot issue in cancer research. Hyperthermia is recognized as a strong sensitizer for radiotherapy and chemotherapy enhancing tumor control without increasing toxicity. Today's electromagnetic hyperthermia systems heat large tissue volumes with limited ability to selectively heat the tumor. Fortunately, tremendous improvements in 3-dimensional electromagnetic & temperature modelling provide an exciting opportunity to design advanced multi-element electromagnetic applicator systems. Together with feedback control using MR non-invasive thermometry and smart E-field sensors, this paves the way for selective tumor heating and potentially prescription of a thermal dose. A technological advanced hyperthermia system, with guaranteed delivery of high quality hyperthermia lowers the threshold for newcomers to apply hyperthermia. Combined with recent proof that hyperthermia blocks DNA repair and new, exciting, ways for controlled drug delivery using temperature sensitive liposome encapsulated drugs, this is expected to increase interest of the medical community in hyperthermia.

Original languageEnglish
Title of host publication2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) : 16-20 Aug. 2016.
Place of PublicationPiscataway
PublisherInstitute of Electrical and Electronics Engineers
Pages359-362
Number of pages4
ISBN (Electronic)978-1-4577-0220-4
ISBN (Print)978-1-4577-0219-8
DOIs
Publication statusPublished - Aug 2016
Externally publishedYes
Event38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2016) - Disney’s Contemporary Resort , Orlando, United States
Duration: 16 Aug 201620 Aug 2016
Conference number: 38
http://embc.embs.org/2016/

Conference

Conference38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2016)
Abbreviated titleEMBC 2016
CountryUnited States
CityOrlando
Period16/08/1620/08/16
Internet address

Keywords

  • Clinical Trials as Topic
  • Electromagnetic Fields
  • Humans
  • Hyperthermia, Induced/methods
  • Microwaves
  • Neoplasms/therapy
  • Temperature

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