Hydroxyapatite particles maintain peri-implant bone mantle during osseointegration in osteoporotic bone

A.E. Tami, M.M. Leitner, M.G. Baucke, T.L. Mueller, G.H. Lenthe, van, R. Müller, K. Ito

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)
2 Downloads (Pure)

Abstract

In osteoporotic bones, resorption exceeds formation during the remodelling phase of bone turnover. As a consequence, decreased bone volume and bone contact result in the peri-implant region. This may subsequently lead to loss of fixation. In this study we investigated whether the presence of nonresorbable, osteoconductive hydroxyapatite (HA) particles could help maintain a denser and more functional peri-implant bone structure. Titanium screws were implanted into the proximal tibial metaphysis of four months old, ovariectomized Wistar rats (n = 60). In the right tibia, the drill hole was first filled with HA particles, while the left tibia served as a control without HA particles. Histological analysis demonstrated that during the remodelling phase the amount of newly formed bone was significantly higher on the HA over the control side. Micro-CT analysis corroborated the significant changes over time as well as differences in peri-implant bone volume density between treatment and control group. Mechanical tests demonstrated that the pull-out force was greater with HA particles. These results indicate that HA particles are able to induce and maintain for a longer time a denser peri-implant bone mantle in osteoporotic bone, which may have important implications in the prevention of implant migration and cut-outs. © 2009 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)1117-1124
JournalBone
Volume45
Issue number6
DOIs
Publication statusPublished - 2009

Fingerprint

Dive into the research topics of 'Hydroxyapatite particles maintain peri-implant bone mantle during osseointegration in osteoporotic bone'. Together they form a unique fingerprint.

Cite this