Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

A.H.A.M. van Onzen; L. Albertazzi; A.P.H.J. Schenning; L.-G. Milroy; L. Brunsveld

doi:10.1039/c6cc08793k

Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

A.H.A.M. van Onzen
, L. Albertazzi
, A.P.H.J. Schenning
, L.-G. Milroy
, L. Brunsveld (Corresponding author)

Chemical Biology

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

151 Downloads (Pure)

Abstract

The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.

Original language	English
Pages (from-to)	1626-1629
Number of pages	4
Journal	Chemical Communications, ChemComm
Volume	53
Issue number	10
DOIs	https://doi.org/10.1039/c6cc08793k
Publication status	Published - 4 Feb 2017

Keywords

Cytosol/chemistry
Fluorescent Dyes/chemical synthesis
HeLa Cells
Humans
Hydrophobic and Hydrophilic Interactions
Nanoparticles/chemistry
Spectrometry, Fluorescence

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10.1039/c6cc08793k

publisher versionFinal published version, 2.52 MBLicence: CC BY-NC

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abstract = "The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.",

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AU - Albertazzi, L.

AU - Schenning, A.P.H.J.

AU - Milroy, L.-G.

AU - Brunsveld, L.

PY - 2017/2/4

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AB - The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.

KW - Cytosol/chemistry

KW - Fluorescent Dyes/chemical synthesis

KW - HeLa Cells

KW - Humans

KW - Hydrophobic and Hydrophilic Interactions

KW - Nanoparticles/chemistry

KW - Spectrometry, Fluorescence

UR - https://www.scopus.com/pages/publications/85010977548

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DO - 10.1039/c6cc08793k

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JF - Chemical Communications, ChemComm

IS - 10

ER -

Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

Abstract

Keywords

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