The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.
- Fluorescent Dyes/chemical synthesis
- HeLa Cells
- Hydrophobic and Hydrophilic Interactions
- Spectrometry, Fluorescence