Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

A.H.A.M. van Onzen, L. Albertazzi, A.P.H.J. Schenning, L.-G. Milroy, L. Brunsveld (Corresponding author)

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The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.

Original languageEnglish
Pages (from-to)1626-1629
Number of pages4
JournalChemical Communications
Issue number10
Publication statusPublished - 4 Feb 2017



  • Cytosol/chemistry
  • Fluorescent Dyes/chemical synthesis
  • HeLa Cells
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Nanoparticles/chemistry
  • Spectrometry, Fluorescence

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