Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

A.H.A.M. van Onzen; L. Albertazzi; A.P.H.J. Schenning; L.-G. Milroy; L. Brunsveld

doi:10.1039/c6cc08793k

Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

A.H.A.M. van Onzen, L. Albertazzi, A.P.H.J. Schenning, L.-G. Milroy, L. Brunsveld (Corresponding author)

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

114 Downloads (Pure)

Abstract

The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.

Original language	English
Pages (from-to)	1626-1629
Number of pages	4
Journal	Chemical Communications, ChemComm
Volume	53
Issue number	10
DOIs	https://doi.org/10.1039/c6cc08793k
Publication status	Published - 4 Feb 2017

Keywords

Cytosol/chemistry
Fluorescent Dyes/chemical synthesis
HeLa Cells
Humans
Hydrophobic and Hydrophilic Interactions
Nanoparticles/chemistry
Spectrometry, Fluorescence

Access to Document

10.1039/c6cc08793k

publisher versionFinal published version, 2.52 MBLicence: CC BY-NC

Cite this

@article{6d372bcab50648e0bfb8578280f3ab4c,

title = "Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells",

abstract = "The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.",

keywords = "Cytosol/chemistry, Fluorescent Dyes/chemical synthesis, HeLa Cells, Humans, Hydrophobic and Hydrophilic Interactions, Nanoparticles/chemistry, Spectrometry, Fluorescence",

author = "{van Onzen}, A.H.A.M. and L. Albertazzi and A.P.H.J. Schenning and L.-G. Milroy and L. Brunsveld",

year = "2017",

month = feb,

day = "4",

doi = "10.1039/c6cc08793k",

language = "English",

volume = "53",

pages = "1626--1629",

journal = "Chemical Communications, ChemComm",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "10",

}

TY - JOUR

T1 - Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

AU - van Onzen, A.H.A.M.

AU - Albertazzi, L.

AU - Schenning, A.P.H.J.

AU - Milroy, L.-G.

AU - Brunsveld, L.

PY - 2017/2/4

Y1 - 2017/2/4

N2 - The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.

AB - The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.

KW - Cytosol/chemistry

KW - Fluorescent Dyes/chemical synthesis

KW - HeLa Cells

KW - Humans

KW - Hydrophobic and Hydrophilic Interactions

KW - Nanoparticles/chemistry

KW - Spectrometry, Fluorescence

UR - http://www.scopus.com/inward/record.url?scp=85010977548&partnerID=8YFLogxK

U2 - 10.1039/c6cc08793k

DO - 10.1039/c6cc08793k

M3 - Article

C2 - 28097276

SN - 1359-7345

VL - 53

SP - 1626

EP - 1629

JO - Chemical Communications, ChemComm

JF - Chemical Communications, ChemComm

IS - 10

ER -

Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this