Hybrid particles derived from alendronate and bioactive glass for treatment of osteoporotic bone defects

Mani Diba, Winston A. Camargo, Tatiana Zinkevich, Alina Grünewald, Rainer Detsch, Yoones Kabiri, Arno P.M. Kentgens, Aldo R. Boccaccini, Jeroen J.J.P. van den Beucken, Sander C.G. Leeuwenburgh (Corresponding author)

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4 Citations (Scopus)

Abstract

Osteoporosis is the most widespread metabolic bone disease which represents a major public health burden. Consequently, novel biomaterials with a strong capacity to regenerate osteoporotic bone defects are urgently required. In view of the anti-osteoporotic and osteopromotive efficacy of alendronate and 45S5 bioactive glass, respectively, we investigated the feasibility to synthesize novel hybrid particles by exploiting the strong interactions between these two compounds. Herein, we demonstrate the facile preparation of a novel class of hybrid particles of tunable morphology, chemical composition and structure. These hybrid particles (i) release alendronate and various inorganic elements (Ca, Na, Si, and P) in a controlled manner, (ii) exhibit a strong anti-osteoclastic effect in vitro, and (iii) stimulate regeneration of osteoporotic bone in vivo. Consequently, this novel class of hybrid biomaterials opens up new avenues of research on the design of bone substitutes with specific activity to facilitate regeneration of bone defects in osteoporotic patients.

Original languageEnglish
Pages (from-to)796-808
Number of pages13
JournalJournal of Materials Chemistry B
Volume7
Issue number5
DOIs
Publication statusPublished - 7 Feb 2019

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    Diba, M., Camargo, W. A., Zinkevich, T., Grünewald, A., Detsch, R., Kabiri, Y., Kentgens, A. P. M., Boccaccini, A. R., van den Beucken, J. J. J. P., & Leeuwenburgh, S. C. G. (2019). Hybrid particles derived from alendronate and bioactive glass for treatment of osteoporotic bone defects. Journal of Materials Chemistry B, 7(5), 796-808. https://doi.org/10.1039/c8tb03062f