Abstract
Designer particles that are embued with nanomachinery for autonomous motion have great potential for biomedical applications; however, their development is highly demanding with respect to biodegradability/compatibility. Previously, biodegradable propulsive machinery based on enzymes has been presented. However, enzymes are highly susceptible to proteolysis and deactivation in biological milieu. Biodegradable hybrid nanomotors powered by catalytic inorganic nanoparticles provide a proteolytically stable alternative to those based upon enzymes. Herein we describe the assembly of hybrid biodegradable nanomotors capable of transducing chemical energy into motion. Such nanomotors are constructed through a process of compartmentalized synthesis of inorganic MnO2 nanoparticles (MnPs) within the cavity of organic stomatocytes. We show that the nanomotors remain active in cellular environments and do not compromise cell viability. Effective tumor penetration of hybrid nanomotors is also demonstrated in proof-of-principle experiments. Overall, this work represents a new prospect for engineering of nanomotors that can retain their functionality within biological contexts.
Original language | English |
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Pages (from-to) | 4472-4480 |
Number of pages | 9 |
Journal | Nano Letters |
Volume | 20 |
Issue number | 6 |
DOIs | |
Publication status | Published - 10 Jun 2020 |
Funding
The authors acknowledge the support from the Dutch Ministry of Education, Culture and Science (Gravitation Program 024.001.035) and NWO-NSFC Advanced Materials (Project 792.001.015). The authors acknowledge the support by the National Natural Science Foundation of China (51561135010). We thank the Spanish MINECO (BOTSinFluids Project), the Foundation BBVA (MEDIROBOTS Project), and the CERCA Program of the Generalitat de Catalunya. We thank the Ser Cymru II Programme for support of D.S.W.; this project received funding from the European Union’s Horizon 2020 Research and Innovation Programme under Marie Skłodowska-Curie Grant Agreement 663830.
Funders | Funder number |
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European Union's Horizon 2020 - Research and Innovation Framework Programme | 663830, 694120 |
National Natural Science Foundation of China | 51561135010 |
Ministerie van Onderwijs, Cultuur en Wetenschap | 024.001.035 |
Ministerio de Economía y Competitividad |
Keywords
- Biodegradable nanomotors
- Biomedical applications
- Compartmentalization
- Hybrid nanosystems
- Stomatocyte
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Center for Multiscale Electron Microscopy (CMEM)
Friedrich, H. (Manager), Bransen, M. (Education/research officer), Schmit, P. (Education/research officer), Schreur - Piet, I. (Other) & Spoelstra, A. (Education/research officer)
Physical ChemistryFacility/equipment: Research lab