TY - JOUR
T1 - Hyaluronic acid and chondroitin sulfate (meth)acrylate-based hydrogels for tissue engineering
T2 - Synthesis, characteristics and pre-clinical evaluation
AU - Schuurmans, Carl C.L.
AU - Mihajlovic, Marko
AU - Hiemstra, Christine
AU - Ito, Keita
AU - Hennink, Wim E.
AU - Vermonden, Tina
PY - 2021/1
Y1 - 2021/1
N2 - Hydrogels based on photocrosslinkable Hyaluronic Acid Methacrylate (HAMA) and Chondroitin Sulfate Methacrylate (CSMA) are presently under investigation for tissue engineering applications. HAMA and CSMA gels offer tunable characteristics such as tailorable mechanical properties, swelling characteristics, and enzymatic degradability. This review gives an overview of the scientific literature published regarding the pre-clinical development of covalently crosslinked hydrogels that (partially) are based on HAMA and/or CSMA. Throughout the review, recommendations for the next steps in clinical translation of hydrogels based on HAMA or CSMA are made and potential pitfalls are defined. Specifically, a myriad of different synthetic routes to obtain polymerizable hyaluronic acid and chondroitin sulfate derivatives are described. The effects of important parameters such as degree of (meth)acrylation and molecular weight of the synthesized polymers on the formed hydrogels are discussed and useful analytical techniques for their characterization are summarized. Furthermore, the characteristics of the formed hydrogels including their enzymatic degradability are discussed. Finally, a summary of several recent applications of these hydrogels in applied fields such as cartilage and cardiac regeneration and advanced tissue modelling is presented.
AB - Hydrogels based on photocrosslinkable Hyaluronic Acid Methacrylate (HAMA) and Chondroitin Sulfate Methacrylate (CSMA) are presently under investigation for tissue engineering applications. HAMA and CSMA gels offer tunable characteristics such as tailorable mechanical properties, swelling characteristics, and enzymatic degradability. This review gives an overview of the scientific literature published regarding the pre-clinical development of covalently crosslinked hydrogels that (partially) are based on HAMA and/or CSMA. Throughout the review, recommendations for the next steps in clinical translation of hydrogels based on HAMA or CSMA are made and potential pitfalls are defined. Specifically, a myriad of different synthetic routes to obtain polymerizable hyaluronic acid and chondroitin sulfate derivatives are described. The effects of important parameters such as degree of (meth)acrylation and molecular weight of the synthesized polymers on the formed hydrogels are discussed and useful analytical techniques for their characterization are summarized. Furthermore, the characteristics of the formed hydrogels including their enzymatic degradability are discussed. Finally, a summary of several recent applications of these hydrogels in applied fields such as cartilage and cardiac regeneration and advanced tissue modelling is presented.
KW - (meth)acrylation
KW - CSMA
KW - Enzymatic degradation
KW - HAMA
KW - In vitro tissue models
KW - Regenerative medicine
UR - http://www.scopus.com/inward/record.url?scp=85098091929&partnerID=8YFLogxK
U2 - 10.1016/j.biomaterials.2020.120602
DO - 10.1016/j.biomaterials.2020.120602
M3 - Review article
C2 - 33360302
AN - SCOPUS:85098091929
SN - 0142-9612
VL - 268
JO - Biomaterials
JF - Biomaterials
M1 - 120602
ER -