How to prepare a systematic review of economic evaluations for informing evidence-based healthcare decisions: a five-step approach (part 1/3)

Ghislaine A.P.G. van Mastrigt, Mickaël Hiligsmann, Jacobus J.C. Arts, Pieter H. Broos, Jos Kleijnen, Silvia M.A.A. Evers, Marian H.J.M. Majoie

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Introduction: Systematic reviews of economic evaluations are useful for synthesizing economic evidence about health interventions and for informing evidence-based decisions. Areas covered: As there is no detailed description of the methods for performing a systematic review of economic evidence, this paper aims to provide an overview of state-of-the-art methodology. This is laid out in a 5-step approach, as follows: step 1) initiating a systematic review; step 2) identifying (full) economic evaluations; step 3) data extraction, risk of bias and transferability assessment; step 4) reporting results; step 5) discussion and interpretation of findings. Expert commentary: The paper aims to help inexperienced reviewers and clinical practice guideline developers, but also to be a resource for experts in the field who want to check on current methodological developments.

Original languageEnglish
Pages (from-to)689-704
Number of pages16
JournalExpert Review of Pharmacoeconomics and Outcomes Research
Issue number6
Publication statusPublished - 1 Nov 2016



  • clinical practice guidelines
  • data extraction
  • databases
  • economic evaluations
  • guidance
  • Methods
  • quality appraisal
  • reporting and discussion
  • risk of bias
  • search strategies
  • systematic reviews

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