We aimed to compare HLA-DQB1-associations in narcolepsy type 1 (NT1) patients with disease onset before and after the 2009 H1N1 pandemic in a large Dutch cohort. 525 NT1 patients and 1272 HLA-DQB1*06:02-positive healthy controls were included. Because of the discussion that has arisen on the existence of sporadic and post-H1N1 NT1, HLA-DQB1-associations in pre- and post-H1N1 NT1 patients were compared. The associations between HLA-DQB1 alleles and NT1 were not significantly different between pre- and post-H1N1 NT1 patients. Both HLA-DQB1-associations with pre- and -post H1N1 NT1 reported in recent smaller studies were replicated. Our findings combine the results of studies in pre- and post-H1N1 NT1 and argue against considering post-H1N1 NT1 as a different entity.
|Number of pages||5|
|Journal||Journal of Neuroimmunology|
|Publication status||Published - 15 May 2020|
Bibliographical noteCopyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
- Auto-immune disease
FingerprintDive into the research topics of 'HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic'. Together they form a unique fingerprint.
Merel M. van Gilst (Content manager) & M.B. (Beatrijs) van der Hout-van der Jagt (Content manager)
Impact: Research Topic/Theme (at group level)