HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic

Mink Schinkelshoek; Rolf Fronczek; Willem Verduijn; Geert Haasnoot; Sebastiaan Overeem; Claire Donjacour; Astrid van der Heide; Dave Roelen; Frans Claas; Gert Jan Lammers

doi:10.1016/j.jneuroim.2020.577210

HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic

Mink Schinkelshoek (Corresponding author), Rolf Fronczek, Willem Verduijn, Geert Haasnoot, Sebastiaan Overeem, Claire Donjacour, Astrid van der Heide, Dave Roelen, Frans Claas, Gert Jan Lammers

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Abstract

We aimed to compare HLA-DQB1-associations in narcolepsy type 1 (NT1) patients with disease onset before and after the 2009 H1N1 pandemic in a large Dutch cohort. 525 NT1 patients and 1272 HLA-DQB1*06:02-positive healthy controls were included. Because of the discussion that has arisen on the existence of sporadic and post-H1N1 NT1, HLA-DQB1-associations in pre- and post-H1N1 NT1 patients were compared. The associations between HLA-DQB1 alleles and NT1 were not significantly different between pre- and post-H1N1 NT1 patients. Both HLA-DQB1-associations with pre- and -post H1N1 NT1 reported in recent smaller studies were replicated. Our findings combine the results of studies in pre- and post-H1N1 NT1 and argue against considering post-H1N1 NT1 as a different entity.

Original language	English
Article number	577210
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	342
DOIs	https://doi.org/10.1016/j.jneuroim.2020.577210
Publication status	Published - 15 May 2020

Bibliographical note

Keywords

Auto-immune disease
H1N1
HLA
Hypocretin
Narcolepsy

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10.1016/j.jneuroim.2020.577210

publishers versionFinal published version, 713 KBLicence: CC BY-NC-ND

Cite this

@article{c25726101a5246228e042e3118c5bbc1,

title = "HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic",

abstract = "We aimed to compare HLA-DQB1-associations in narcolepsy type 1 (NT1) patients with disease onset before and after the 2009 H1N1 pandemic in a large Dutch cohort. 525 NT1 patients and 1272 HLA-DQB1*06:02-positive healthy controls were included. Because of the discussion that has arisen on the existence of sporadic and post-H1N1 NT1, HLA-DQB1-associations in pre- and post-H1N1 NT1 patients were compared. The associations between HLA-DQB1 alleles and NT1 were not significantly different between pre- and post-H1N1 NT1 patients. Both HLA-DQB1-associations with pre- and -post H1N1 NT1 reported in recent smaller studies were replicated. Our findings combine the results of studies in pre- and post-H1N1 NT1 and argue against considering post-H1N1 NT1 as a different entity.",

keywords = "Auto-immune disease, H1N1, HLA, Hypocretin, Narcolepsy",

author = "Mink Schinkelshoek and Rolf Fronczek and Willem Verduijn and Geert Haasnoot and Sebastiaan Overeem and Claire Donjacour and {van der Heide}, Astrid and Dave Roelen and Frans Claas and Lammers, {Gert Jan}",

year = "2020",

month = may,

day = "15",

doi = "10.1016/j.jneuroim.2020.577210",

language = "English",

volume = "342",

journal = "Journal of Neuroimmunology",

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T1 - HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic

AU - Schinkelshoek, Mink

AU - Fronczek, Rolf

AU - Verduijn, Willem

AU - Haasnoot, Geert

AU - Overeem, Sebastiaan

AU - Donjacour, Claire

AU - van der Heide, Astrid

AU - Roelen, Dave

AU - Claas, Frans

AU - Lammers, Gert Jan

PY - 2020/5/15

Y1 - 2020/5/15

N2 - We aimed to compare HLA-DQB1-associations in narcolepsy type 1 (NT1) patients with disease onset before and after the 2009 H1N1 pandemic in a large Dutch cohort. 525 NT1 patients and 1272 HLA-DQB1*06:02-positive healthy controls were included. Because of the discussion that has arisen on the existence of sporadic and post-H1N1 NT1, HLA-DQB1-associations in pre- and post-H1N1 NT1 patients were compared. The associations between HLA-DQB1 alleles and NT1 were not significantly different between pre- and post-H1N1 NT1 patients. Both HLA-DQB1-associations with pre- and -post H1N1 NT1 reported in recent smaller studies were replicated. Our findings combine the results of studies in pre- and post-H1N1 NT1 and argue against considering post-H1N1 NT1 as a different entity.

AB - We aimed to compare HLA-DQB1-associations in narcolepsy type 1 (NT1) patients with disease onset before and after the 2009 H1N1 pandemic in a large Dutch cohort. 525 NT1 patients and 1272 HLA-DQB1*06:02-positive healthy controls were included. Because of the discussion that has arisen on the existence of sporadic and post-H1N1 NT1, HLA-DQB1-associations in pre- and post-H1N1 NT1 patients were compared. The associations between HLA-DQB1 alleles and NT1 were not significantly different between pre- and post-H1N1 NT1 patients. Both HLA-DQB1-associations with pre- and -post H1N1 NT1 reported in recent smaller studies were replicated. Our findings combine the results of studies in pre- and post-H1N1 NT1 and argue against considering post-H1N1 NT1 as a different entity.

KW - Auto-immune disease

KW - H1N1

KW - HLA

KW - Hypocretin

KW - Narcolepsy

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DO - 10.1016/j.jneuroim.2020.577210

M3 - Article

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SN - 0165-5728

VL - 342

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

M1 - 577210

ER -

HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic

Abstract

Bibliographical note

Keywords

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Sleep Medicine

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HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic

Abstract

Bibliographical note

Keywords

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Impacts

Sleep Medicine

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