HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic

Mink Schinkelshoek (Corresponding author), Rolf Fronczek, Willem Verduijn, Geert Haasnoot, Sebastiaan Overeem, Claire Donjacour, Astrid van der Heide, Dave Roelen, Frans Claas, Gert Jan Lammers

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Abstract

We aimed to compare HLA-DQB1-associations in narcolepsy type 1 (NT1) patients with disease onset before and after the 2009 H1N1 pandemic in a large Dutch cohort. 525 NT1 patients and 1272 HLA-DQB1*06:02-positive healthy controls were included. Because of the discussion that has arisen on the existence of sporadic and post-H1N1 NT1, HLA-DQB1-associations in pre- and post-H1N1 NT1 patients were compared. The associations between HLA-DQB1 alleles and NT1 were not significantly different between pre- and post-H1N1 NT1 patients. Both HLA-DQB1-associations with pre- and -post H1N1 NT1 reported in recent smaller studies were replicated. Our findings combine the results of studies in pre- and post-H1N1 NT1 and argue against considering post-H1N1 NT1 as a different entity.

Original languageEnglish
Article number577210
Number of pages5
JournalJournal of Neuroimmunology
Volume342
DOIs
Publication statusPublished - 15 May 2020

Bibliographical note

Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Keywords

  • Auto-immune disease
  • H1N1
  • HLA
  • Hypocretin
  • Narcolepsy

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