Highlighting the nuances behind interaction of picosecond pulses with human skin: Relating distinct laser-tissue interactions to their potential in cutaneous interventions

Natallia E. Uzunbajakava, Babu Varghese, Natalia V. Botchkareva, Rieko Verhagen, Alfred Vogel

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    In recent years, several commercial systems relying on picosecond pulses have been introduced into the field of cutaneous interventions. In parallel with this development, a somewhat distinct research prototype also operating in the picosecond regime was described in literature. Albeit both market-available products and the investigational device employ laser beams of nearly the same pulse duration and were reported to cause laser-induced optical breakdown (LIOB), they are different in terms of wavelength, applied fluence, laser beam quality, optical architecture and related focusing optics, resulting in different histomorphological features (such as e.g. lesion size, location, expression of collagen). Understanding the differences between these systems in relation to implications for clinical results raises a need in highlighting the nuances behind interaction of picosecond pulses with biological tissue. To achieve this, we accentuate the interplay of irradiance levels of picosecond pulses in W/cm2, absorption properties of a target tissue at a wavelength of a light source and resulting interaction mechanisms with biological object. We also relate these nuances to potential consequences for cutaneous interventions.

    Original languageEnglish
    Title of host publicationOptical Interactions with Tissue and Cells XXIX
    EditorsE. Duco Jansen, Hope Thomas Beier
    PublisherSPIE
    ISBN (Electronic)9781510614697
    DOIs
    Publication statusPublished - 2018
    EventOptical Interactions with Tissue and Cells XXIX 2018 - San Francisco, United States
    Duration: 29 Jan 201830 Jan 2018

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume10492
    ISSN (Print)1605-7422

    Conference

    ConferenceOptical Interactions with Tissue and Cells XXIX 2018
    CountryUnited States
    CitySan Francisco
    Period29/01/1830/01/18

    Keywords

    • Laser-induced optical breakdown (LIOB)
    • laser-tissue interaction
    • multiphoton ionization-induced LIOB (MI-LIOB)
    • photo-thermo-mechanical disruption (PTMD)
    • photodisruption
    • picosecond laser device
    • plasma-induced ablation
    • thermionic emission-induced LIOB (TILIOB)

    Fingerprint Dive into the research topics of 'Highlighting the nuances behind interaction of picosecond pulses with human skin: Relating distinct laser-tissue interactions to their potential in cutaneous interventions'. Together they form a unique fingerprint.

    Cite this