TY - JOUR
T1 - Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes—The Maastricht Study
AU - Sörensen, Ben M.
AU - van der Heide, Frank C.T.
AU - Houben, Alfons J.H.M.
AU - Koster, Annemarie
AU - Berendschot, Tos T.J.M.
AU - Schouten, Jan S.A.G.
AU - Kroon, Abraham A.
AU - van der Kallen, Carla J.H.
AU - Henry, Ronald M.A.
AU - van Dongen, Martien C.J.M.
AU - Eussen, Simone J.P.M.
AU - Savelberg, Hans H.C.M.
AU - van der Berg, Julianne D.
AU - Schaper, Nicolaas C.
AU - Schram, Miranda T.
AU - Stehouwer, Coen D.A.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Objective: Physical activity may provide a means for the prevention of cardiovascular disease via improving microvascular function. Therefore, this study investigated whether physical activity is associated with skin and retinal microvascular function. Methods: In The Maastricht Study, a population-based cohort study enriched with type 2 diabetes (n = 1298, 47.3% women, aged 60.2 ± 8.1 years, 29.5% type 2 diabetes), we studied whether accelerometer-assessed physical activity and sedentary time associate with skin and retinal microvascular function. Associations were studied by linear regression and adjusted for major cardiovascular risk factors. In addition, we investigated whether associations were stronger in type 2 diabetes. Results: In individuals with type 2 diabetes, total physical activity and higher-intensity physical activity were independently associated with greater heat-induced skin hyperemia (regression coefficients per hour), respectively, 10 (95% CI: 1; 18) and 36 perfusion units (14; 58). In individuals without type 2 diabetes, total physical activity and higher-intensity physical activity were not associated with heat-induced skin hyperemia. No associations with retinal arteriolar %-dilation were identified. Conclusion: Higher levels of total and higher-intensity physical activity were associated with greater skin microvascular vasodilation in individuals with, but not in those without, type 2 diabetes.
AB - Objective: Physical activity may provide a means for the prevention of cardiovascular disease via improving microvascular function. Therefore, this study investigated whether physical activity is associated with skin and retinal microvascular function. Methods: In The Maastricht Study, a population-based cohort study enriched with type 2 diabetes (n = 1298, 47.3% women, aged 60.2 ± 8.1 years, 29.5% type 2 diabetes), we studied whether accelerometer-assessed physical activity and sedentary time associate with skin and retinal microvascular function. Associations were studied by linear regression and adjusted for major cardiovascular risk factors. In addition, we investigated whether associations were stronger in type 2 diabetes. Results: In individuals with type 2 diabetes, total physical activity and higher-intensity physical activity were independently associated with greater heat-induced skin hyperemia (regression coefficients per hour), respectively, 10 (95% CI: 1; 18) and 36 perfusion units (14; 58). In individuals without type 2 diabetes, total physical activity and higher-intensity physical activity were not associated with heat-induced skin hyperemia. No associations with retinal arteriolar %-dilation were identified. Conclusion: Higher levels of total and higher-intensity physical activity were associated with greater skin microvascular vasodilation in individuals with, but not in those without, type 2 diabetes.
KW - cohort studies
KW - diabetes mellitus
KW - type 2
KW - exercise
KW - microcirculation
KW - sedentary behavior
UR - http://www.scopus.com/inward/record.url?scp=85081255302&partnerID=8YFLogxK
U2 - 10.1111/micc.12611
DO - 10.1111/micc.12611
M3 - Article
C2 - 31997430
SN - 1073-9688
VL - 27
JO - Microcirculation
JF - Microcirculation
IS - 4
M1 - e12611
ER -
