High-throughput screening of cell-surface topographic interactions

Hemant V. Unadkat, Marc Hulsman, Kamiel Cornelissen, Bernke Papenburg, Roman K. Truckenmüller, Gerhard F. Post, Marc Uetz, Marcel J.T. Reinders, Dimitrios Stamatialis, Clemens Van Blitterswijk, Jan De Boer

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

High throughput biomaterials screening largely remains unexplored. The present study was an attempt to explore the area of high throughput as well as high content screening of cell surface topographic interaction. An array of surface topographies called TopoChip was fabricated using a widely used polymer in tissue engineering, Poly (DL-lactic acid). The topographies were subsequently screened for their mitogenic effect on cells. We were able to detect topographic parameters responsible for mitogenic effect of surface topographies.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages2083-2084
Number of pages2
Publication statusPublished - 1 Dec 2010
Externally publishedYes
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 3 Oct 20107 Oct 2010
Conference number: 14
http://www.microtasconferences.org/microtas2010/

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume3

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Abbreviated titleMicroTAS 2010
Country/TerritoryNetherlands
CityGroningen
Period3/10/107/10/10
Internet address

Keywords

  • Biomaterials
  • Cell behavior
  • High-throughput screening
  • Micro-nanotopographies

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