High-throughput screening of cell-surface topographic interactions

Hemant V. Unadkat; Marc Hulsman; Kamiel Cornelissen; Bernke Papenburg; Roman K. Truckenmüller; Gerhard F. Post; Marc Uetz; Marcel J.T. Reinders; Dimitrios Stamatialis; Clemens Van Blitterswijk; Jan De Boer

High-throughput screening of cell-surface topographic interactions

Hemant V. Unadkat, Marc Hulsman, Kamiel Cornelissen, Bernke Papenburg, Roman K. Truckenmüller, Gerhard F. Post, Marc Uetz, Marcel J.T. Reinders, Dimitrios Stamatialis, Clemens Van Blitterswijk, Jan De Boer

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

High throughput biomaterials screening largely remains unexplored. The present study was an attempt to explore the area of high throughput as well as high content screening of cell surface topographic interaction. An array of surface topographies called TopoChip was fabricated using a widely used polymer in tissue engineering, Poly (DL-lactic acid). The topographies were subsequently screened for their mitogenic effect on cells. We were able to detect topographic parameters responsible for mitogenic effect of surface topographies.

Original language	English
Title of host publication	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages	2083-2084
Number of pages	2
Publication status	Published - 1 Dec 2010
Externally published	Yes
Event	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2010 - Groningen, Netherlands Duration: 3 Oct 2010 → 7 Oct 2010 Conference number: 14 http://www.microtasconferences.org/microtas2010/

Conference

Conference	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2010
Abbreviated title	MicroTAS 2010
Country/Territory	Netherlands
City	Groningen
Period	3/10/10 → 7/10/10
Internet address	http://www.microtasconferences.org/microtas2010/

Keywords

Biomaterials
Cell behavior
High-throughput screening
Micro-nanotopographies

Cite this

Unadkat, H. V., Hulsman, M., Cornelissen, K., Papenburg, B., Truckenmüller, R. K., Post, G. F., Uetz, M., Reinders, M. J. T., Stamatialis, D., Van Blitterswijk, C., & De Boer, J. (2010). High-throughput screening of cell-surface topographic interactions. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 2083-2084)

@inproceedings{4fdc0d8395a0403394dbb5260e12f5b5,

title = "High-throughput screening of cell-surface topographic interactions",

abstract = "High throughput biomaterials screening largely remains unexplored. The present study was an attempt to explore the area of high throughput as well as high content screening of cell surface topographic interaction. An array of surface topographies called TopoChip was fabricated using a widely used polymer in tissue engineering, Poly (DL-lactic acid). The topographies were subsequently screened for their mitogenic effect on cells. We were able to detect topographic parameters responsible for mitogenic effect of surface topographies.",

keywords = "Biomaterials, Cell behavior, High-throughput screening, Micro-nanotopographies",

author = "Unadkat, {Hemant V.} and Marc Hulsman and Kamiel Cornelissen and Bernke Papenburg and Truckenm{\"u}ller, {Roman K.} and Post, {Gerhard F.} and Marc Uetz and Reinders, {Marcel J.T.} and Dimitrios Stamatialis and {Van Blitterswijk}, Clemens and {De Boer}, Jan",

year = "2010",

month = dec,

day = "1",

language = "English",

isbn = "9781618390622",

pages = "2083--2084",

booktitle = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",

note = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2010, MicroTAS 2010 ; Conference date: 03-10-2010 Through 07-10-2010",

url = "http://www.microtasconferences.org/microtas2010/",

}

Unadkat, HV, Hulsman, M, Cornelissen, K, Papenburg, B, Truckenmüller, RK, Post, GF, Uetz, M, Reinders, MJT, Stamatialis, D, Van Blitterswijk, C & De Boer, J 2010, High-throughput screening of cell-surface topographic interactions. in 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. pp. 2083-2084, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2010, Groningen, Netherlands, 3/10/10.

High-throughput screening of cell-surface topographic interactions. / Unadkat, Hemant V.; Hulsman, Marc; Cornelissen, Kamiel et al.
14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. p. 2083-2084.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - High-throughput screening of cell-surface topographic interactions

AU - Unadkat, Hemant V.

AU - Hulsman, Marc

AU - Cornelissen, Kamiel

AU - Papenburg, Bernke

AU - Truckenmüller, Roman K.

AU - Post, Gerhard F.

AU - Uetz, Marc

AU - Reinders, Marcel J.T.

AU - Stamatialis, Dimitrios

AU - Van Blitterswijk, Clemens

AU - De Boer, Jan

N1 - Conference code: 14

PY - 2010/12/1

Y1 - 2010/12/1

N2 - High throughput biomaterials screening largely remains unexplored. The present study was an attempt to explore the area of high throughput as well as high content screening of cell surface topographic interaction. An array of surface topographies called TopoChip was fabricated using a widely used polymer in tissue engineering, Poly (DL-lactic acid). The topographies were subsequently screened for their mitogenic effect on cells. We were able to detect topographic parameters responsible for mitogenic effect of surface topographies.

AB - High throughput biomaterials screening largely remains unexplored. The present study was an attempt to explore the area of high throughput as well as high content screening of cell surface topographic interaction. An array of surface topographies called TopoChip was fabricated using a widely used polymer in tissue engineering, Poly (DL-lactic acid). The topographies were subsequently screened for their mitogenic effect on cells. We were able to detect topographic parameters responsible for mitogenic effect of surface topographies.

KW - Biomaterials

KW - Cell behavior

KW - High-throughput screening

KW - Micro-nanotopographies

UR - http://www.scopus.com/inward/record.url?scp=84884336962&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84884336962

SN - 9781618390622

SP - 2083

EP - 2084

BT - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

T2 - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2010

Y2 - 3 October 2010 through 7 October 2010

ER -

High-throughput screening of cell-surface topographic interactions

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Keywords

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