Hierarchical formation of supramolecular transient networks in water : a modular injectable delivery system

P.Y.W. Dankers; T.M. Hermans; T.W. Baughman; Y. Kamikawa; R.E. Kieltyka; M.M.C. Bastings; H.M. Janssen; N.A.J.M. Sommerdijk; A. Larsen; M.J.A. Luyn, van; A.W. Bosman; E.R. Popa; G. Fytas; E.W. Meijer

doi:10.1002/adma.201104072

Hierarchical formation of supramolecular transient networks in water : a modular injectable delivery system

P.Y.W. Dankers, T.M. Hermans, T.W. Baughman, Y. Kamikawa, R.E. Kieltyka, M.M.C. Bastings, H.M. Janssen, N.A.J.M. Sommerdijk, A. Larsen, M.J.A. Luyn, van, A.W. Bosman, E.R. Popa, G. Fytas, E.W. Meijer

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Abstract

A modular one-component supramolecular transient network in water, based on poly(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution.

Original language	English
Pages (from-to)	2703-2709
Number of pages	7
Journal	Advanced Materials
Volume	24
Issue number	20
DOIs	https://doi.org/10.1002/adma.201104072
Publication status	Published - 2012

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10.1002/adma.201104072

Center for Multiscale Electron Microscopy (CMEM)
Friedrich, H. (Manager), Joosten, R. (Education/research officer), Schmit, P. (Education/research officer), Schreur - Piet, I. (Other) & Spoelstra, A. (Education/research officer)
Physical Chemistry
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Dankers, P. Y. W., Hermans, T. M., Baughman, T. W., Kamikawa, Y., Kieltyka, R. E., Bastings, M. M. C., Janssen, H. M., Sommerdijk, N. A. J. M., Larsen, A., Luyn, van, M. J. A., Bosman, A. W., Popa, E. R., Fytas, G., & Meijer, E. W. (2012). Hierarchical formation of supramolecular transient networks in water : a modular injectable delivery system. Advanced Materials, 24(20), 2703-2709. https://doi.org/10.1002/adma.201104072

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abstract = "A modular one-component supramolecular transient network in water, based on poly(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution.",

author = "P.Y.W. Dankers and T.M. Hermans and T.W. Baughman and Y. Kamikawa and R.E. Kieltyka and M.M.C. Bastings and H.M. Janssen and N.A.J.M. Sommerdijk and A. Larsen and {Luyn, van}, M.J.A. and A.W. Bosman and E.R. Popa and G. Fytas and E.W. Meijer",

year = "2012",

doi = "10.1002/adma.201104072",

language = "English",

volume = "24",

pages = "2703--2709",

journal = "Advanced Materials",

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Dankers, PYW, Hermans, TM, Baughman, TW, Kamikawa, Y, Kieltyka, RE, Bastings, MMC, Janssen, HM, Sommerdijk, NAJM, Larsen, A, Luyn, van, MJA, Bosman, AW, Popa, ER, Fytas, G & Meijer, EW 2012, 'Hierarchical formation of supramolecular transient networks in water : a modular injectable delivery system', Advanced Materials, vol. 24, no. 20, pp. 2703-2709. https://doi.org/10.1002/adma.201104072

TY - JOUR

T1 - Hierarchical formation of supramolecular transient networks in water : a modular injectable delivery system

AU - Dankers, P.Y.W.

AU - Hermans, T.M.

AU - Baughman, T.W.

AU - Kamikawa, Y.

AU - Kieltyka, R.E.

AU - Bastings, M.M.C.

AU - Janssen, H.M.

AU - Sommerdijk, N.A.J.M.

AU - Larsen, A.

AU - Luyn, van, M.J.A.

AU - Bosman, A.W.

AU - Popa, E.R.

AU - Fytas, G.

AU - Meijer, E.W.

PY - 2012

Y1 - 2012

N2 - A modular one-component supramolecular transient network in water, based on poly(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution.

AB - A modular one-component supramolecular transient network in water, based on poly(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution.

U2 - 10.1002/adma.201104072

DO - 10.1002/adma.201104072

M3 - Article

C2 - 22528786

SN - 0935-9648

VL - 24

SP - 2703

EP - 2709

JO - Advanced Materials

JF - Advanced Materials

IS - 20

ER -

Hierarchical formation of supramolecular transient networks in water : a modular injectable delivery system

Abstract

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