Harnessing human plasmacytoid dendritic cells as professional APCs

Jurjen Tel; Anne M. van der Leun; Carl G. Figdor; Ruurd Torensma; L. Jolanda M. de Vries

doi:10.1007/s00262-012-1210-z

Harnessing human plasmacytoid dendritic cells as professional APCs

Jurjen Tel, Anne M. van der Leun, Carl G. Figdor, Ruurd Torensma, L. Jolanda M. de Vries

Research output: Contribution to journal › Article › Academic › peer-review

48 Citations (Scopus)

Abstract

The plasmacytoid dendritic cell (pDC) constitutes a unique DC subset that links the innate and adaptive arm of the immune system. Whereas the unique capability of pDCs to produce large amounts of type I IFNs in response to pathogen recognition is generally accepted,their antigen-presenting function is often neglected since most studies on antigen presentation are aimed at other DC subsets. Recently, pDCs were demonstrated capable to present antigen leading to protective tumor immunity. In this review, we discuss how pDCs could be exploited in the fight against cancer by analyzing their capacity to capture,process and (cross-) present antigen.

Original language	English
Pages (from-to)	1279-88
Number of pages	10
Journal	Cancer Immunology, Immunotherapy
Volume	61
Issue number	8
DOIs	https://doi.org/10.1007/s00262-012-1210-z
Publication status	Published - Aug 2012
Externally published	Yes

Keywords

Animals
Antigen Presentation
Antigen-Presenting Cells
Congresses as Topic
Dendritic Cells
Humans
Immunotherapy, Adoptive
Neoplasms
Journal Article
Research Support, Non-U.S. Gov't
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00262-012-1210-z

Cite this

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title = "Harnessing human plasmacytoid dendritic cells as professional APCs",

abstract = "The plasmacytoid dendritic cell (pDC) constitutes a unique DC subset that links the innate and adaptive arm of the immune system. Whereas the unique capability of pDCs to produce large amounts of type I IFNs in response to pathogen recognition is generally accepted,their antigen-presenting function is often neglected since most studies on antigen presentation are aimed at other DC subsets. Recently, pDCs were demonstrated capable to present antigen leading to protective tumor immunity. In this review, we discuss how pDCs could be exploited in the fight against cancer by analyzing their capacity to capture,process and (cross-) present antigen.",

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language = "English",

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pages = "1279--88",

journal = "Cancer Immunology, Immunotherapy",

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T1 - Harnessing human plasmacytoid dendritic cells as professional APCs

AU - Tel, Jurjen

AU - van der Leun, Anne M.

AU - Figdor, Carl G.

AU - Torensma, Ruurd

AU - de Vries, L. Jolanda M.

PY - 2012/8

Y1 - 2012/8

N2 - The plasmacytoid dendritic cell (pDC) constitutes a unique DC subset that links the innate and adaptive arm of the immune system. Whereas the unique capability of pDCs to produce large amounts of type I IFNs in response to pathogen recognition is generally accepted,their antigen-presenting function is often neglected since most studies on antigen presentation are aimed at other DC subsets. Recently, pDCs were demonstrated capable to present antigen leading to protective tumor immunity. In this review, we discuss how pDCs could be exploited in the fight against cancer by analyzing their capacity to capture,process and (cross-) present antigen.

AB - The plasmacytoid dendritic cell (pDC) constitutes a unique DC subset that links the innate and adaptive arm of the immune system. Whereas the unique capability of pDCs to produce large amounts of type I IFNs in response to pathogen recognition is generally accepted,their antigen-presenting function is often neglected since most studies on antigen presentation are aimed at other DC subsets. Recently, pDCs were demonstrated capable to present antigen leading to protective tumor immunity. In this review, we discuss how pDCs could be exploited in the fight against cancer by analyzing their capacity to capture,process and (cross-) present antigen.

KW - Animals

KW - Antigen Presentation

KW - Antigen-Presenting Cells

KW - Congresses as Topic

KW - Dendritic Cells

KW - Humans

KW - Immunotherapy, Adoptive

KW - Neoplasms

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1007/s00262-012-1210-z

DO - 10.1007/s00262-012-1210-z

M3 - Article

C2 - 22294456

VL - 61

SP - 1279

EP - 1288

JO - Cancer Immunology, Immunotherapy

JF - Cancer Immunology, Immunotherapy

SN - 0340-7004

IS - 8

ER -

Harnessing human plasmacytoid dendritic cells as professional APCs

Abstract

Keywords

UN SDGs

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