Harnessing human plasmacytoid dendritic cells as professional APCs

Jurjen Tel, Anne M. van der Leun, Carl G. Figdor, Ruurd Torensma, L. Jolanda M. de Vries

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)

Abstract

The plasmacytoid dendritic cell (pDC) constitutes a unique DC subset that links the innate and adaptive arm of the immune system. Whereas the unique capability of pDCs to produce large amounts of type I IFNs in response to pathogen recognition is generally accepted,their antigen-presenting function is often neglected since most studies on antigen presentation are aimed at other DC subsets. Recently, pDCs were demonstrated capable to present antigen leading to protective tumor immunity. In this review, we discuss how pDCs could be exploited in the fight against cancer by analyzing their capacity to capture,process and (cross-) present antigen.

Original languageEnglish
Pages (from-to)1279-88
Number of pages10
JournalCancer Immunology, Immunotherapy
Volume61
Issue number8
DOIs
Publication statusPublished - Aug 2012
Externally publishedYes

Keywords

  • Animals
  • Antigen Presentation
  • Antigen-Presenting Cells
  • Congresses as Topic
  • Dendritic Cells
  • Humans
  • Immunotherapy, Adoptive
  • Neoplasms
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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