Good and bad consequences of altered fatty acid metabolism in heart failure: Evidence from mouse models

D. Abdurrachim; J.J.F.P. Luiken; K. Nicolay; J.F.C. Glatz; J.J. Prompers; M. Nabben

doi:10.1093/cvr/cvv105

Good and bad consequences of altered fatty acid metabolism in heart failure: Evidence from mouse models

D. Abdurrachim, J.J.F.P. Luiken, K. Nicolay, J.F.C. Glatz, J.J. Prompers, M. Nabben

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Abstract

The shift in substrate preference away from fatty acid oxidation (FAO) towards increased glucose utilization in heart failure has long been interpreted as an oxygen-sparing mechanism. Inhibition of FAO has therefore evolved as an accepted approach to treat heart failure. However, recent data indicate that increased reliance on glucose might be detrimental rather than beneficial for the failing heart. This review discusses new insights into metabolic adaptations in heart failure. A particular focus lies on data obtained from mouse models with modulations of cardiac FA metabolism at different levels of the FA metabolic pathway and how these differently affect cardiac function. Based on studies in which these mouse models were exposed to ischaemic and non-ischaemic heart failure, we discuss whether and when modulations in FA metabolism are protective against heart failure.

Original language	English
Pages (from-to)	194-205
Number of pages	12
Journal	Cardiovascular Research
Volume	106
Issue number	2
DOIs	https://doi.org/10.1093/cvr/cvv105
Publication status	Published - 1 May 2015

Keywords

Energy metabolism
Genetically altered mice
Heart failure
Metabolic shift

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abstract = "The shift in substrate preference away from fatty acid oxidation (FAO) towards increased glucose utilization in heart failure has long been interpreted as an oxygen-sparing mechanism. Inhibition of FAO has therefore evolved as an accepted approach to treat heart failure. However, recent data indicate that increased reliance on glucose might be detrimental rather than beneficial for the failing heart. This review discusses new insights into metabolic adaptations in heart failure. A particular focus lies on data obtained from mouse models with modulations of cardiac FA metabolism at different levels of the FA metabolic pathway and how these differently affect cardiac function. Based on studies in which these mouse models were exposed to ischaemic and non-ischaemic heart failure, we discuss whether and when modulations in FA metabolism are protective against heart failure.",

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AU - Glatz, J.F.C.

AU - Prompers, J.J.

AU - Nabben, M.

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Good and bad consequences of altered fatty acid metabolism in heart failure: Evidence from mouse models

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