Golden beam data for proton pencil-beam scanning

B. Clasie, N. Depauw, M.A.L.J. Fransen, C. Goma, H.R. Panahandeh, J. Seco, J.B. Flanz, H.M. Kooy

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Abstract

Proton, as well as other ion, beams applied by electro-magnetic deflection in pencil-beam scanning (PBS) are minimally perturbed and thus can be quantified a priori by their fundamental interactions in a medium. This a priori quantification permits an optimal reduction of characterizing measurements on a particular PBS delivery system. The combination of a priori quantification and measurements will then suffice to fully describe the physical interactions necessary for treatment planning purposes. We consider, for proton beams, these interactions and derive a 'Golden' beam data set. The Golden beam data set quantifies the pristine Bragg peak depth-dose distribution in terms of primary, multiple Coulomb scatter, and secondary, nuclear scatter, components. The set reduces the required measurements on a PBS delivery system to the measurement of energy spread and initial phase space as a function of energy. The depth doses are described in absolute units of Gy(RBE) mm2 Gp-1, where Gp equals 109 (giga) protons, thus providing a direct mapping from treatment planning parameters to integrated beam current. We used these Golden beam data on our PBS delivery systems and demonstrated that they yield absolute dosimetry well within clinical tolerance.
Original languageEnglish
Pages (from-to)1147-1158
Number of pages12
JournalPhysics in Medicine and Biology
Volume57
Issue number5
DOIs
Publication statusPublished - 2012

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Clasie, B., Depauw, N., Fransen, M. A. L. J., Goma, C., Panahandeh, H. R., Seco, J., ... Kooy, H. M. (2012). Golden beam data for proton pencil-beam scanning. Physics in Medicine and Biology, 57(5), 1147-1158. https://doi.org/10.1088/0031-9155/57/5/1147
Clasie, B. ; Depauw, N. ; Fransen, M.A.L.J. ; Goma, C. ; Panahandeh, H.R. ; Seco, J. ; Flanz, J.B. ; Kooy, H.M. / Golden beam data for proton pencil-beam scanning. In: Physics in Medicine and Biology. 2012 ; Vol. 57, No. 5. pp. 1147-1158.
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Clasie, B, Depauw, N, Fransen, MALJ, Goma, C, Panahandeh, HR, Seco, J, Flanz, JB & Kooy, HM 2012, 'Golden beam data for proton pencil-beam scanning', Physics in Medicine and Biology, vol. 57, no. 5, pp. 1147-1158. https://doi.org/10.1088/0031-9155/57/5/1147

Golden beam data for proton pencil-beam scanning. / Clasie, B.; Depauw, N.; Fransen, M.A.L.J.; Goma, C.; Panahandeh, H.R.; Seco, J.; Flanz, J.B.; Kooy, H.M.

In: Physics in Medicine and Biology, Vol. 57, No. 5, 2012, p. 1147-1158.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Clasie, B.

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Clasie B, Depauw N, Fransen MALJ, Goma C, Panahandeh HR, Seco J et al. Golden beam data for proton pencil-beam scanning. Physics in Medicine and Biology. 2012;57(5):1147-1158. https://doi.org/10.1088/0031-9155/57/5/1147