Glucose-responsive enzyme-controlled mesoporous nanomachine with a layer-by-layer supramolecular architecture

Sandra Jimenez-Falcao, Beatriz De Luis, Alba García-Fernández, Antoni Llopis-Lorente, Paula Diez, Alfredo Sánchez, Félix Sancenón, Paloma Martínez-Ruiz (Corresponding author), Ramón Martínez-Máñez (Corresponding author), Reynaldo Villalonga (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)


Here we describe the construction of an integrated and pH-sensitive nanomachine with layer-by-layer supramolecular design and enzymatic control for on-command delivery. The nanodevice comprises a first layer of β-cyclodextrin-coated gold nanoparticles as capping element of benzimidazole functionalized mesoporous silica nanoparticles, and a second control layer based on an adatamantane-modified glucose oxidase derivative. The nanomachine was selectively fuelled by glucose and successfully employed for the autonomous release of doxorubicin in HeLa cancer cells.

Original languageEnglish
Pages (from-to)3321-3328
Number of pages8
JournalACS Applied Bio Materials
Issue number8
Publication statusPublished - 19 Aug 2019
Externally publishedYes


  • cyclodextrin
  • delivery
  • enzymes
  • gold nanoparticles
  • mesoporous silica


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