GC/MS and the chromatographic challenge

P.A. Leclercq, C.A.M.G. Cramers

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic


Application of high pressure drop (narrow-bore, vacuum-outlet) columns shortens analysis times and lowers detection limits at least in proportion to the reduced column diameter. In the scanning mode in GC/MS, only quadrupole instruments can meet this challenge for columns (with 105 plates I with diameters down to 30-50 mum. For still faster separations on even smaller bore columns only simultaneous ion collecting mass spectrometers are suited (e.g. time-of-flight instruments, magnetic mass spectrometers with "electronic" photoplates). The hitherto experienced bottleneck, the transport of vast amounts of mass spectral data per time unit to mass storage devices, can nowadays be overcome by storing all data in ever cheaper and ever expanding computer memory. Theoretically, there is no limit in gas chromatographic separation speed. One might speculate on GC/MS on the MS/MS time scale of mus. Current research indicates, however, that 10 mum i.d. columns are the limit in practice.
Original languageEnglish
Title of host publicationNinth International Symposium on Capillary Chromatography, Monterey, California, USA, May 16-19, 1988
EditorsP. Sandra
Place of PublicationHeidelberg
Publication statusPublished - 1988
Event9th International Symposium on Capillary Chromatography - Conference Center, Monterey, United States
Duration: 16 May 198819 May 1988


Conference9th International Symposium on Capillary Chromatography
Country/TerritoryUnited States


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