Furosemide in preterm infants treated with indomethacin for patent ductus arteriosus

Peter Andriessen (Corresponding author), Nicole C. Struis, Hendrik Niemarkt, Sidarto Bambang Oetomo, Ronald B. Tanke, Bart Van Overmeire

    Research output: Contribution to journalArticleAcademicpeer-review

    23 Citations (Scopus)


    Objective: To evaluate the effect of furosemide on renal function and water balance in preterm infants treated with indomethacin (3 × 0.2 mg/kg at 12-h intervals) for symptomatic patent ductus arteriosus. Patients and Methods: We performed a retrospective multi-centre double cohort study in preterm infants <32 weeks of gestational age. Thirty-two infants treated with furosemide (1 mg/kg i.v.) before each indomethacin dose (furosemide group) were matched with 32 infants with indomethacin treatment alone (control-group). Renal effects (urine output, weight gain, serum creatinine, sodium concentration) were registered. Results: The study groups were comparable for gestational age, birth weight and day of therapy. Pretreatment differences were observed for urine output, weight and serum sodium. However, no differences were noticed in day-to-day urine output change or weight gain between the groups. A significant increase in serum creatinine concentration (50% vs. control, 18%; p < 0.05) and a concomitant significant decrease in serum sodium (-9 vs. control, -3 mmoL/L; p < 0.05) in the furosemide group was observed 72-96 h after starting therapy. Conclusion: Furosemide before each indomethacin dose resulted in a significant increase in serum creatinine and hyponatremia, without increasing urine output.

    Original languageEnglish
    Pages (from-to)797-803
    Number of pages7
    JournalActa Paediatrica, International Journal of Paediatrics
    Issue number5
    Publication statusPublished - 1 May 2009


    • Furosemide
    • Indomethacin
    • Patent ductus arteriosus
    • Renal function


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