Functionalization of protein-based nanocages for drug delivery applications

L. Schoonen, J.C.M. van Hest

Research output: Contribution to journalReview articlepeer-review

147 Citations (Scopus)


Traditional drug delivery strategies involve drugs which are not targeted towards the desired tissue. This can lead to undesired side effects, as normal cells are affected by the drugs as well. Therefore, new systems are now being developed which combine targeting functionalities with encapsulation of drug cargo. Protein nanocages are highly promising drug delivery platforms due to their perfectly defined structures, biocompatibility, biodegradability and low toxicity. A variety of protein nanocages have been modified and functionalized for these types of applications. In this review, we aim to give an overview of different types of modifications of protein-based nanocontainers for drug delivery applications.

Original languageEnglish
Pages (from-to)7124-7141
Number of pages18
Issue number13
Publication statusPublished - 7 Jul 2014
Externally publishedYes


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