Functional SYNTAX score for risk assessment in multivessel coronary artery disease

Chang Wook Nam, Fabio Mangiacapra, Robert Entjes, In Sung Chung, Jan Willem Sels, Pim A.L. Tonino, Bernard De Bruyne, Nico H.J. Pijls, William F. Fearon

Research output: Contribution to journalArticleAcademicpeer-review

235 Citations (SciVal)


Objectives: This study was aimed at investigating whether a fractional flow reserve (FFR)-guided SYNTAX score (SS), termed "functional SYNTAX score" (FSS), would predict clinical outcome better than the classic SS in patients with multivessel coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). Background: The SS is a purely anatomic score based on the coronary angiogram and predicts outcome after PCI in patients with multivessel CAD. FFR-guided PCI improves outcomes by adding functional information to the anatomic information obtained from the angiogram. Methods: The SS was prospectively collected in 497 patients enrolled in the FAME (Fractional Flow Reserve versus Angiography for Multivessel Evaluation) study. FSS was determined by only counting ischemia-producing lesions (FFR ≤0.80). The ability of each score to predict major adverse cardiac events (MACE) at 1 year was compared. Results: The 497 patients were divided into tertiles of risk based on the SS. After determining the FSS for each patient, 32% moved to a lower-risk group as follows. MACE occurred in 9.0%, 11.3%, and 26.7% of patients in the low-, medium-, and high-FSS groups, respectively (p < 0.001). Only FSS and procedure time were independent predictors of 1-year MACE. FSS demonstrated a better predictive accuracy for MACE compared with SS (Harrell's C of FSS, 0.677 vs. SS, 0.630, p = 0.02; integrated discrimination improvement of 1.94%, p < 0.001). Conclusions: Recalculating SS by only incorporating ischemia-producing lesions as determined by FFR decreases the number of higher-risk patients and better discriminates risk for adverse events in patients with multivessel CAD undergoing PCI.

Original languageEnglish
Pages (from-to)1211-1218
Number of pages8
JournalJournal of the American College of Cardiology
Issue number12
Publication statusPublished - 13 Sept 2011


  • coronary angiography
  • coronary artery disease
  • fractional flow reserve
  • percutaneous coronary intervention
  • risk assessment


Dive into the research topics of 'Functional SYNTAX score for risk assessment in multivessel coronary artery disease'. Together they form a unique fingerprint.

Cite this