Abstract
The use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brings. However, the blood is also a source of (immune) cells and proteins that dominantly contribute to functional tissue regeneration. This review explores the potential of the blood as a source for the complete or partial in situ regeneration of cardiovascular tissues, with a particular focus on the endothelium, being the natural blood-tissue barrier. We pinpoint the current scientific challenges to enable rational engineering and testing of blood-contacting implants to leverage the regenerative potential of the blood.
| Original language | English |
|---|---|
| Article number | 115085 |
| Number of pages | 22 |
| Journal | Advanced Drug Delivery Reviews |
| Volume | 201 |
| DOIs | |
| Publication status | Published - Oct 2023 |
Bibliographical note
Copyright © 2023. Published by Elsevier B.V.UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Cardiovascular disease
- Endothelial heterogeneity
- Endothelial progenitor cells
- Endothelialization
- Heart valve
- Immunomodulatory biomaterials
- In situ tissue engineering
- Monocytes
- Total artificial heart
- Vascular graft
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