Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy

Jacobus F.A. Jansen; Albert P. Aldenkamp; H.J.M. Majoie; Rianne P. Reijs; Marc C.T.F.M. de Krom; Paul A.M. Hofman; M.E. Kooi; Klaas Nicolay; Walter H. Backes

doi:10.1016/j.yebeh.2006.05.004

Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy

Jacobus F.A. Jansen (Corresponding author), Albert P. Aldenkamp, H.J.M. Majoie, Rianne P. Reijs, Marc C.T.F.M. de Krom, Paul A.M. Hofman, M.E. Kooi, Klaas Nicolay, Walter H. Backes

Research output: Contribution to journal › Article › Academic › peer-review

68 Citations (Scopus)

Abstract

Functional magnetic resonance imaging of covert word generation was used to examine brain activation abnormalities associated with topiramate-induced cognitive language impairment in patients with epilepsy. Compared with a control epilepsy group, in the topiramate-treated group, there was significantly less activation in the language-mediating regions of the prefrontal cortex; the topiramate group also had significantly lower neuropsychological language scores. These findings suggest that topiramate has a critical effect on the cerebral neural systems that mediate expressive language.

Original language	English
Pages (from-to)	181-185
Number of pages	5
Journal	Epilepsy and Behavior
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/j.yebeh.2006.05.004
Publication status	Published - 1 Aug 2006

Keywords

Cognition
Epilepsy
Functional magnetic resonance imaging
Language
Neuropsychology
Topiramate

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10.1016/j.yebeh.2006.05.004

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title = "Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy",

abstract = "Functional magnetic resonance imaging of covert word generation was used to examine brain activation abnormalities associated with topiramate-induced cognitive language impairment in patients with epilepsy. Compared with a control epilepsy group, in the topiramate-treated group, there was significantly less activation in the language-mediating regions of the prefrontal cortex; the topiramate group also had significantly lower neuropsychological language scores. These findings suggest that topiramate has a critical effect on the cerebral neural systems that mediate expressive language.",

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AU - Jansen, Jacobus F.A.

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AU - Majoie, H.J.M.

AU - Reijs, Rianne P.

AU - de Krom, Marc C.T.F.M.

AU - Hofman, Paul A.M.

AU - Kooi, M.E.

AU - Nicolay, Klaas

AU - Backes, Walter H.

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AB - Functional magnetic resonance imaging of covert word generation was used to examine brain activation abnormalities associated with topiramate-induced cognitive language impairment in patients with epilepsy. Compared with a control epilepsy group, in the topiramate-treated group, there was significantly less activation in the language-mediating regions of the prefrontal cortex; the topiramate group also had significantly lower neuropsychological language scores. These findings suggest that topiramate has a critical effect on the cerebral neural systems that mediate expressive language.

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KW - Epilepsy

KW - Functional magnetic resonance imaging

KW - Language

KW - Neuropsychology

KW - Topiramate

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Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy

Abstract

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