Functional growth in tissue engineered living, vascular grafts : follow up at 100 weeks in a large animal model

S.P. Hoerstrup, I.G. Cummings, M. Lachat, F.J. Schoen, R. Jenni, S. Leschka, S. Neuenschwander, D. Schmidt, A. Driessen - Mol, C.I. Günter, M. Goessi, M. Genoni, G. Zund

Research output: Contribution to journalArticleAcademicpeer-review

152 Citations (Scopus)

Abstract

Background-: Living autologous vascular grafts with the capacity for regeneration and growth may overcome the limitations of contemporary artificial prostheses. Particularly in congenital cardiovascular surgery, there is an unmet medical need for growing replacement materials. Here we investigate growth capacity of tissue-engineered living pulmonary arteries in a growing lamb model. Methods and Results-: Vascular grafts fabricated from biodegradable scaffolds (ID 18+/-l mm) were sequentially seeded with vascular cells. The seeded constructs were grown in vitro for 21days using biomimetic conditions. Thereafter, these tissue-engineered vascular grafts (TEVGs) were surgically implanted as main pulmonary artery replacements in 14 lambs using cardiopulmonary bypass and followed up for
Original languageEnglish
Pages (from-to)I-159-I-66
JournalCirculation
Volume114
Issue number1
DOIs
Publication statusPublished - 2006

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